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Literature summary extracted from

  • Inkster, M.E.; Cotter, M.A.; Cameron, N.E.
    Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats (2007), Eur. J. Pharmacol., 561, 63-71.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.17.3.2 pharmacology inhibition of xanthine oxidase is a potential therapeutic approach to diabetic neuropathy and vasculopathy Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol treatment with the inhibitor improves nerve and vascular function in diabetic rats, sciatic nerve and superior cervical ganglion blood flow is halved by diabetes and allopurinol corrects this by approximately 63%, Ngamma-nitro-L-arginine acts as an antagonist, effects on diabetic and non-diabetic rats, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Rattus norvegicus xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes, overview urate + H2O2
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Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Rattus norvegicus
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 male sprague-dawley rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Rattus norvegicus urate + H2O2
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1.17.3.2 xanthine + H2O + O2 xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes, overview Rattus norvegicus urate + H2O2
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