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Literature summary extracted from

  • Wang, Q.P.; Jammoul, F.; Duboc, A.; Gong, J.; Simonutti, M.; Dubus, E.; Craft, C.M.; Ye, W.; Sahel, J.A.; Picaud, S.
    Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina (2008), Eur. J. Neurosci., 27, 2177-2187.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 vigabatrin triggers a massive synaptic plasticity in retinal areas showing a normal layering of the retina shown by the withdrawal of rod but not cone photoreceptor terminals from the outer plexiform layers towards their cell bodies. Both rod bipolar cells and horizontal cells exhibit dendritic sprouting into the photoreceptor nuclear layer. Withdrawing rod photoreceptors appear to form ectopic contacts with growing postsynaptic dendrites. Neuronal plasticity is highly suggestive of an impaired glutamate release by photoreceptors Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 retina retinal tissue of albino mice treated with two vigabatrin doses Mus musculus
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