Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Scholz, M.; Ulbrich, H.K.; Dannhardt, G.
    Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles (2008), Eur. J. Med. Chem., 43, 1152-1159.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 4,5-bis(4-chlorophenyl)-1,2-selenazole 44% inhibition at 0.01 mM Bos taurus
1.13.11.34 4,5-bis(4-methoxyphenyl)-1,2-selenazole 58% inhibition at 0.01 mM Bos taurus
1.13.11.34 4-(4-chlorophenyl)-5-(4-methoxyphenyl)-1,2-selenazole 53% inhibition at 0.01 mM Bos taurus
1.13.11.34 4-(4-chlorophenyl)-5-p-tolyl-1,2-selenazole 45% inhibition at 0.01 mM Bos taurus
1.13.11.34 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-1,2-selenazole 60% inhibition at 0.01 mM Bos taurus
1.13.11.34 5-(4-chlorophenyl)-4-(4-methoxyphenyl)-1,2-selenazole 42% inhibition at 0.01 mM Bos taurus
1.13.11.34 5-(4-chlorophenyl)-4-p-tolyl-1,2-selenazole 67% inhibition at 0.01 mM Bos taurus
1.13.11.34 5-(4-methoxyphenyl)-4-p-tolyl-1,2-selenazole 64% inhibition at 0.01 mM Bos taurus
1.13.11.34 celecoxib
-
 Bos taurus
1.13.11.34 ebselen 54% inhibition at 0.01 mM Bos taurus
1.13.11.34 additional information docking and molecular modeling studies, overview Bos taurus
1.13.11.34 nordihydroguaiaretic acid
-
 Bos taurus
1.13.11.34 thioctic acid
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Bos taurus
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2 Bos taurus
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 leukocyte polymorphonuclear Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Bos taurus leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Bos taurus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2
-
 Bos taurus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-LOX
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.001
-
-
 Bos taurus nordihydroguaiaretic acid
1.13.11.34 0.008
-
-
 Bos taurus 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-1,2-selenazole