EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.187 | N-ethylmaleimide | preincubation with malonyl-CoA or methylmalonyl-CoA protects | Klebsiella pneumoniae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.39 | 0.016 | - |
malonyl-CoA | pH 7.5, 37°C | Klebsiella pneumoniae | |
2.3.1.39 | 0.016 | - |
methylmalonyl-CoA | pH 7.5, 37°C | Klebsiella pneumoniae | |
2.3.1.187 | 0.016 | - |
malonyl-CoA | pH 7.0 | Klebsiella pneumoniae | |
2.3.1.187 | 0.016 | - |
methylmalonyl-CoA | pH 7.0 | Klebsiella pneumoniae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.39 | Klebsiella pneumoniae | O32717 | - |
- |
2.3.1.187 | Klebsiella pneumoniae | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.39 | malonyl-CoA + acyl-carrier protein | - |
Klebsiella pneumoniae | CoA + malonyl-[acyl-carrier protein] | - |
? | |
2.3.1.39 | methylmalonyl-CoA + acyl-carrier protein | - |
Klebsiella pneumoniae | CoA + methylmalonyl-[acyl-carrier protein] | - |
? | |
2.3.1.39 | additional information | presence of malonyl-CoA:ACP transacylase MdcH is required for catalytic activity of malonate decarboxylase. Substrates for MdcH are malonyl-CoA or methylmalonyl-CoA but not acetyl-CoA. Transfer of the methylmalonyl-residue to the prosthetic group proceeds via the covalent methylmalonyl-MdcH intermediate | Klebsiella pneumoniae | ? | - |
? | |
2.3.1.187 | malonyl-CoA + dephospho-CoA | - |
Klebsiella pneumoniae | CoA + malonyl-dephospho-CoA | - |
? | |
2.3.1.187 | methylmalonyl-CoA + dephospho-CoA | transfer proceeds via a covalent methylmalonyl-enzyme intermediate | Klebsiella pneumoniae | CoA + methylmalonyl-dephospho-CoA | - |
? | |
2.3.1.187 | additional information | no substrate: acetyl-CoA | Klebsiella pneumoniae | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.39 | tetramer | malonate decarboxylase consists of the four subunits MdcA, MdcD, MdcE and MdcC in an apparent 1:1:1:1 stoichiometry. The preparation contains substoichiometric amounts of malonyl-CoA:ACP transacylase MdcH comigrating on SDS/PAGE with MdcD | Klebsiella pneumoniae |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.39 | MdcH | - |
Klebsiella pneumoniae |
2.3.1.187 | malonyl-CoA:ACP transacylase | - |
Klebsiella pneumoniae |
2.3.1.187 | MdcH | - |
Klebsiella pneumoniae |