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Literature summary extracted from

  • Hoenke, S.; Dimroth, P.
    Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected] (1999), Eur. J. Biochem., 259, 181-187.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.187 N-ethylmaleimide preincubation with malonyl-CoA or methylmalonyl-CoA protects Klebsiella pneumoniae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.39 0.016
-
malonyl-CoA pH 7.5, 37°C Klebsiella pneumoniae
2.3.1.39 0.016
-
methylmalonyl-CoA pH 7.5, 37°C Klebsiella pneumoniae
2.3.1.187 0.016
-
malonyl-CoA pH 7.0 Klebsiella pneumoniae
2.3.1.187 0.016
-
methylmalonyl-CoA pH 7.0 Klebsiella pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.39 Klebsiella pneumoniae O32717
-
-
2.3.1.187 Klebsiella pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.39 malonyl-CoA + acyl-carrier protein
-
Klebsiella pneumoniae CoA + malonyl-[acyl-carrier protein]
-
?
2.3.1.39 methylmalonyl-CoA + acyl-carrier protein
-
Klebsiella pneumoniae CoA + methylmalonyl-[acyl-carrier protein]
-
?
2.3.1.39 additional information presence of malonyl-CoA:ACP transacylase MdcH is required for catalytic activity of malonate decarboxylase. Substrates for MdcH are malonyl-CoA or methylmalonyl-CoA but not acetyl-CoA. Transfer of the methylmalonyl-residue to the prosthetic group proceeds via the covalent methylmalonyl-MdcH intermediate Klebsiella pneumoniae ?
-
?
2.3.1.187 malonyl-CoA + dephospho-CoA
-
Klebsiella pneumoniae CoA + malonyl-dephospho-CoA
-
?
2.3.1.187 methylmalonyl-CoA + dephospho-CoA transfer proceeds via a covalent methylmalonyl-enzyme intermediate Klebsiella pneumoniae CoA + methylmalonyl-dephospho-CoA
-
?
2.3.1.187 additional information no substrate: acetyl-CoA Klebsiella pneumoniae ?
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.39 tetramer malonate decarboxylase consists of the four subunits MdcA, MdcD, MdcE and MdcC in an apparent 1:1:1:1 stoichiometry. The preparation contains substoichiometric amounts of malonyl-CoA:ACP transacylase MdcH comigrating on SDS/PAGE with MdcD Klebsiella pneumoniae

Synonyms

EC Number Synonyms Comment Organism
2.3.1.39 MdcH
-
Klebsiella pneumoniae
2.3.1.187 malonyl-CoA:ACP transacylase
-
Klebsiella pneumoniae
2.3.1.187 MdcH
-
Klebsiella pneumoniae