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Literature summary extracted from

  • Rodriguez, C.; Rodriguez-Sinovas, A.; Martinez-Gonzalez, J.
    Lysyl oxidase as a potential therapeutic target (2008), Drug News Perspect., 21, 218-224.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.13 tumor growth factor-beta1 stabilizes LOX mRNA leading to an increase in LOX activity Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 2-mercaptopyridine-N-oxide
-
 Mus musculus
1.4.3.13 alpha2-Macroglobulin
-
 Mus musculus
1.4.3.13 beta-aminopropionitrile
-
 Mus musculus
1.4.3.13 heparin
-
 Mus musculus
1.4.3.13 homocysteine thiolactone
-
 Mus musculus
1.4.3.13 low-density lipoprotein down-regulates LOX expression Mus musculus
1.4.3.13 taurine
-
 Mus musculus
1.4.3.13 tumor necrosis factor-alpha down-regulates LOX expression Mus musculus
1.4.3.13 vitamin B3
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.13 cytosol
-
 Mus musculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.13 Cu2+ dependent Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.13 32000
-
 mature and catalytically active enzyme, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 LOX
-
 Mus musculus
1.4.3.13 lysyl oxidase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.13 lysyl-tyrosyl-quinone
-
 Mus musculus