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Literature summary extracted from

  • Stefan, N.; Peter, A.; Cegan, A.; Staiger, H.; Machann, J.; Schick, F.; Claussen, C.D.; Fritsche, A.; Haering, H.U.; Schleicher, E.
    Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans (2008), Diabetologia, 51, 648-656.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview oleoyl-CoA + ferricytochrome b5 + H2O
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Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver hepatic SCD1 activity index correlates negatively with liver fat and positively with insulin sensitivity, overview Homo sapiens
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.1 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
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Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O
-
?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
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Homo sapiens
1.14.19.1 stearoyl-CoA desaturase 1
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Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 ferrocytochrome b5
-
Homo sapiens