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Literature summary extracted from
- Male lower urinary tract symptoms: treatment with alpha-blockers, 5-alpha-reductase inhibitors, antimuscarinics, or a combination (2007), Curr. Urol. Rep., 8, 370-372.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.22 | dutasteride | inhibitor of isoenzymes 5-alpha-reductase type 1 and type 2 | Homo sapiens |  |
| 1.3.1.22 | finasteride | 5 mg/day, selective inhibitor of isoenzyme 5-alpha-reductase type 2 | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.22 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.22 | testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.22 | 5-alpha-reductase type 1 | isozyme | Homo sapiens |
| 1.3.1.22 | 5-alpha-reductase type 2 | isozyme | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.22 | NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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