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Literature summary extracted from
- New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways (2007), Curr. Top. Med. Chem., 7, 297-309.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | drug development | the enzyme is a target in drug design for cancer therapy, inhibitors inclinical trials, overview | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.13.11.34 | DNA and amino acid sequence analysis | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.34 | ER-34122 | - |
Homo sapiens |  |
| 1.13.11.34 | licofelone | formerly termed ML-3000 | Homo sapiens | |
| 1.13.11.34 | RWJ-63556 | - |
Homo sapiens | |
| 1.13.11.34 | S-2474 | - |
Homo sapiens | |
| 1.13.11.34 | tepoxalin | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.13.11.34 | cytosol | - |
Homo sapiens | 5829 | - |
| 1.13.11.34 | additional information | upon cell activation, cytosolic and nuclear enzyme translocates the nuclear envelope, where it interacts with phospholipase A2, making free arachidonate available for 5-LO, and with 5-LO activating protein, i.e. FLAP | Homo sapiens | - |
- |
| 1.13.11.34 | nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Homo sapiens | - |
leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 via stereospecific hydration by LTA4 hydrolase, LTA4 induces VEGF transcription in malignant mesothelial cells, the enzyme is upregulated in cancer cells and is pro-angiogenic | ? | |
| 1.13.11.34 | arachidonic acid + O2 | Homo sapiens | - |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
| 1.13.11.34 | additional information | Homo sapiens | key enzyme in biosynthesis of leukotrienes, overview. Upon cell activation, cytosolic and nuclear enzyme translocates the nuclear envelope, where it interacts with phospholipase A2, making free arachidonate available for 5-LO, and with 5-LO activating protein, i.e. FLAP. 5-LO regulates cancer cell survival and interferes with the mechanismtumor suppression, and increases cancer cell chemoresistance, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | carcinoma cell | of diverse tissues, e.g. colon, lung breast, prostate, pancreas, bone, brain, and mesothelial cancer cells | Homo sapiens | - |
| 1.13.11.34 | colonic cancer cell | high enzyme expression level | Homo sapiens | - |
| 1.13.11.34 | colorectal adenocarcinoma cell | high enzyme expression level | Homo sapiens | - |
| 1.13.11.34 | glioma cell | high enzyme expression level | Homo sapiens | - |
| 1.13.11.34 | lung cancer cell | high enzyme expression level | Homo sapiens | - |
| 1.13.11.34 | pancreatic cancer cell | high enzyme expression level | Homo sapiens | - |
| 1.13.11.34 | prostate cancer cell | high enzyme expression level | Homo sapiens | - |
| 1.13.11.34 | T-lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 via stereospecific hydration by LTA4 hydrolase, LTA4 induces VEGF transcription in malignant mesothelial cells, the enzyme is upregulated in cancer cells and is pro-angiogenic | ? | |
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | stereospecific removal of the pro-R hydrogen at C10 resulting in epoxide formation | Homo sapiens | leukotriene A4 + H2O | - |
? | |
| 1.13.11.34 | arachidonic acid + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
| 1.13.11.34 | arachidonic acid + O2 | stereospecific abstraction of the pro-S hydrogen at C7, followed by insertion of molecular O2 at C5 | Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
| 1.13.11.34 | additional information | key enzyme in biosynthesis of leukotrienes, overview. Upon cell activation, cytosolic and nuclear enzyme translocates the nuclear envelope, where it interacts with phospholipase A2, making free arachidonate available for 5-LO, and with 5-LO activating protein, i.e. FLAP. 5-LO regulates cancer cell survival and interferes with the mechanismtumor suppression, and increases cancer cell chemoresistance, overview | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | ? | x * 72000-80000 | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | 5-lipoxygenase | - |
Homo sapiens |
| 1.13.11.34 | 5-LO | - |
Homo sapiens |
| 1.13.11.34 | arachidonate 5-LO | - |
Homo sapiens |
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