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Literature summary extracted from

  • Zhou, S.; Chowbay, B.
    Clinical significance of thiopurine S-methyltransferase gene polymorphisms (2007), Curr. Pharmacogenomics, 5, 103-115.
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 A154T polymorphism TPMT*3B Mammalia
2.1.1.67 A154T/Y240C polymorphism TPMT*3A Mammalia
2.1.1.67 A154T/Y240C/E98STOP polymorphism TPMT*3D Mammalia
2.1.1.67 A80P polymorphism TPMT*2 Mammalia
2.1.1.67 C132Y polymorphism TPMT*11 Mammalia
2.1.1.67 E28V polymorphism TPMT*13 Mammalia
2.1.1.67 G144R polymorphism TPMT*10 Mammalia
2.1.1.67 G36S/K238E polymorphism TPMT*20 Mammalia
2.1.1.67 G71R polymorphism TPMT*18 Mammalia
2.1.1.67 H227E polymorphism TPMT*7 Mammalia
2.1.1.67 K122T polymorphism TPMT*19 Mammalia
2.1.1.67 L49S polymorphism TPMT*5 Mammalia
2.1.1.67 L69V polymorphism TPMT*21 Mammalia
2.1.1.67 additional information no amino acid substitutions in the polymorphisms TPMT*4 and TPMT*15, Met-Val substitution in the start codon of TPMT*14 Mammalia
2.1.1.67 Q42E polymorphism TPMT*17 Mammalia
2.1.1.67 R163H polymorphism TPMT*16 Mammalia
2.1.1.67 R163P polymorphism TPMT*22 Mammalia
2.1.1.67 R215H polymorphism TPMT*8 Mammalia
2.1.1.67 S125L polymorphism TPMT*12 Mammalia
2.1.1.67 Y180F polymorphism TPMT*6 Mammalia
2.1.1.67 Y240C polymorphism TPMT*3C Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 aspirin
-
 Mammalia
2.1.1.67 bendroflumethiazide
-
 Mammalia
2.1.1.67 Disulfiram
-
 Mammalia
2.1.1.67 Furosemide
-
 Mammalia
2.1.1.67 mesalazine
-
 Mammalia
2.1.1.67 olsalazine
-
 Mammalia
2.1.1.67 sulfasalazine
-
 Mammalia
2.1.1.67 trichlormethiazide
-
 Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytosol
-
 Mammalia 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.67 35000
-
-
 Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Mammalia
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 erythrocyte
-
 Mammalia
-
2.1.1.67 heart
-
 Mammalia
-
2.1.1.67 intestine
-
 Mammalia
-
2.1.1.67 kidney
-
 Mammalia
-
2.1.1.67 liver
-
 Mammalia
-
2.1.1.67 lymphocyte
-
 Mammalia
-
2.1.1.67 pancreas
-
 Mammalia
-
2.1.1.67 placenta
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Mammalia S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Mammalia S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine-monophosphate
-
 Mammalia S-adenosyl-L-homocysteine + 6-methylthioinosine-monophosphate
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Mammalia S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + azathioprine azathioprine is converted to mercaptopurine, which is subsequently metabolized through TPMT Mammalia S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine S-methyltransferase
-
 Mammalia
2.1.1.67 TPMT
-
 Mammalia