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Literature summary extracted from

  • Dunkel, P.; Gelain, A.; Barlocco, D.; Haider, N.; Gyires, K.; Sperlagh, B.; Magyar, K.; Maccioni, E.; Fadda, A.; Matyus, P.
    Semicarbazide-sensitive amine oxidase/vascular adhesion protein 1: recent developments concerning substrates and inhibitors of a promising therapeutic target (2008), Curr. Med. Chem., 15, 1827-1839.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (2-methylprop-2-en-1-yl)hydrazine
-
 Homo sapiens
1.4.3.4 (2-phenylprop-2-en-1-yl)hydrazine
-
 Homo sapiens
1.4.3.4 (2R)-1-(3-methoxyphenoxy)-3-(1-methylhydrazino)propan-2-ol
-
 Rattus norvegicus
1.4.3.4 (2S)-1-(3-methoxyphenoxy)-3-(1-methylhydrazino)propan-2-ol
-
 Rattus norvegicus
1.4.3.4 1-(1-methylhydrazino)-3-(phenylthio)propan-2-ol
-
 Rattus norvegicus
1.4.3.4 1-(1-methylhydrazino)-3-[methyl(phenyl)amino]propan-2-ol
-
 Rattus norvegicus
1.4.3.4 1-[3-(4-chlorophenoxy)-2-methoxypropyl]-1-methylhydrazine
-
 Rattus norvegicus
1.4.3.4 2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
-
 Homo sapiens
1.4.3.4 2-(aminooxy)-1-phenylethanol
-
 Homo sapiens
1.4.3.4 fumarate
-
 Rattus norvegicus
1.4.3.4 malate
-
 Rattus norvegicus
1.4.3.4 succinate
-
 Rattus norvegicus
1.4.3.4 [(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
-
 Homo sapiens
1.4.3.4 [2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
-
 Homo sapiens
1.4.3.4 [2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
-
 Homo sapiens
1.4.3.4 [2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
 Homo sapiens
1.4.3.21 (2-methylprop-2-en-1-yl)hydrazine
-
 Bos taurus
1.4.3.21 (2-phenylprop-2-en-1-yl)hydrazine
-
 Bos taurus
1.4.3.21 (2-phenylprop-2-en-1-yl)hydrazine
-
 Rattus norvegicus
1.4.3.21 (2E)-3-chloroprop-2-en-1-amine
-
 Bos taurus
1.4.3.21 (2Z)-3-chloroprop-2-en-1-amine
-
 Bos taurus
1.4.3.21 1-(2,5-dihydro-1H-pyrrol-3-yl)isoquinoline
-
 Bos taurus
1.4.3.21 1-(isoquinolin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
 Homo sapiens
1.4.3.21 1-ethyl-2-[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
 Rattus norvegicus
1.4.3.21 1-[2-(4-fluorophenyl)prop-2-en-1-yl]-2-methylhydrazine
-
 Rattus norvegicus
1.4.3.21 2-(2,5-dihydro-1H-pyrrol-3-yl)pyridine
-
 Bos taurus
1.4.3.21 2-(4-[2-[2-(acetylamino)-2,3-dihydro-1,3-thiazol-4-yl]ethyl]phenyl)-N-[amino(imino)methyl]acetamide
-
 Homo sapiens
1.4.3.21 2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
-
 Bos taurus
1.4.3.21 2-(aminooxy)-1-phenylethanol
-
 Bos taurus
1.4.3.21 2-([[4-(1,1-dimethylpropyl)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide
-
 Homo sapiens
1.4.3.21 2-amino-N-[2-fluoro-3-(trifluoromethyl)benzyl]acetamide
-
 Rattus norvegicus
1.4.3.21 2-amino-N-[2-fluoro-5-(trifluoromethyl)benzyl]acetamide
-
 Rattus norvegicus
1.4.3.21 2-amino-N-[3-fluoro-5-(trifluoromethyl)benzyl]acetamide
-
 Rattus norvegicus
1.4.3.21 2-amino-N-[4-fluoro-3-(trifluoromethyl)benzyl]acetamide
-
 Rattus norvegicus
1.4.3.21 2-[(biphenyl-4-ylacetyl)amino]pentanedioic acid
-
 Homo sapiens
1.4.3.21 3-(2,5-dihydro-1H-pyrrol-3-yl)pyridine
-
 Bos taurus
1.4.3.21 3-(4-methoxyphenyl)-N-methyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Rattus norvegicus
1.4.3.21 3-bromoprop-2-yn-1-amine
-
 Bos taurus
1.4.3.21 3-[2-(3-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrole
-
 Rattus norvegicus
1.4.3.21 4-(2-naphthyloxy)but-2-yn-1-amine
-
 Bos taurus
1.4.3.21 4-(4-methoxyphenoxy)but-2-yn-1-amine
-
 Bos taurus
1.4.3.21 4-(4-methylphenoxy)but-2-yn-1-amine
-
 Bos taurus
1.4.3.21 4-(4-nitrophenoxy)but-2-yn-1-amine
-
 Bos taurus
1.4.3.21 4-amino-3-hydroxy-N-(3-phenylpropyl)benzamide
-
 Homo sapiens
1.4.3.21 4-aminobut-2-ynenitrile
-
 Bos taurus
1.4.3.21 4-bromo-N-[2-(hydroxyamino)-2-oxoethyl]benzamide
-
 Homo sapiens
1.4.3.21 4-phenoxybut-2-yn-1-amine
-
 Bos taurus
1.4.3.21 5-amino-2-hydroxy-N-(3-phenylpropyl)benzamide
-
 Homo sapiens
1.4.3.21 but-3-yn-1-amine
-
 Bos taurus
1.4.3.21 buta-2,3-dien-1-amine
-
 Bos taurus
1.4.3.21 N,3-dihydroxy-2-[(2-naphthylsulfonyl)amino]butanamide
-
 Homo sapiens
1.4.3.21 N-allyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Rattus norvegicus
1.4.3.21 N-ethyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Rattus norvegicus
1.4.3.21 N-[2-(hydroxyamino)-2-oxoethyl]-2-(2-methyl-1H-indol-3-yl)acetamide
-
 Homo sapiens
1.4.3.21 N-[4-(2-[4-[(2-amino-1H-imidazol-5-yl)methyl]phenyl]ethyl)-1,3-thiazol-2-yl]acetamide
-
 Homo sapiens
1.4.3.21 N-[4-[2-(4-carbamimidamidophenyl)ethyl]-5-(4-sulfamoylbenzyl)-1,3-thiazol-2-yl]acetamide
-
 Homo sapiens
1.4.3.21 N-[4-[2-(4-[[amino(imino)methyl]amino]phenyl)ethyl]-1,3-thiazol-2-yl]acetamide
-
 Homo sapiens
1.4.3.21 [(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
-
 Rattus norvegicus
1.4.3.21 [2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
-
 Rattus norvegicus
1.4.3.21 [2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
-
 Rattus norvegicus
1.4.3.21 [2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397
-
-
1.4.3.4 Homo sapiens P27338
-
-
1.4.3.4 Rattus norvegicus
-
-
-
1.4.3.21 Bos taurus
-
-
-
1.4.3.21 Homo sapiens
-
-
-
1.4.3.21 Mus musculus
-
-
-
1.4.3.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.21 adipose tissue
-
 Homo sapiens
-
1.4.3.21 blood plasma
-
 Homo sapiens
-
1.4.3.21 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 1-(4-fluorophenyl)methanamine + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 1-(4-fluorophenyl)methanamine + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 2-phenylethanamine + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 2-phenylethanamine + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 3-phenylpropan-1-amine + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 3-phenylpropan-1-amine + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 4-phenylbutan-1-amine + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 4-phenylbutan-1-amine + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Mus musculus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Bos taurus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?
1.4.3.21 N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
-
 Bos taurus ? + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO
-
 Rattus norvegicus
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 MAO-B
-
 Homo sapiens
1.4.3.21 SSAO
-
 Mus musculus
1.4.3.21 SSAO
-
 Homo sapiens
1.4.3.21 SSAO
-
 Rattus norvegicus
1.4.3.21 SSAO
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.00047
-
-
 Rattus norvegicus fumarate
1.4.3.4 0.00062
-
-
 Rattus norvegicus succinate
1.4.3.4 0.00065
-
-
 Homo sapiens [(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
1.4.3.4 0.0007
-
-
 Rattus norvegicus malate
1.4.3.4 0.001
-
-
 Homo sapiens [2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.4 0.0013
-
-
 Homo sapiens (2-phenylprop-2-en-1-yl)hydrazine
1.4.3.4 0.002
-
-
 Homo sapiens [2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
1.4.3.4 0.0028
-
-
 Homo sapiens [(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
1.4.3.4 0.006
-
-
 Homo sapiens [2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.4 0.02
-
-
 Homo sapiens (2-methylprop-2-en-1-yl)hydrazine
1.4.3.4 0.0245
-
-
 Homo sapiens [2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.4 0.036
-
-
 Homo sapiens 2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
1.4.3.4 0.071
-
-
 Homo sapiens (2-phenylprop-2-en-1-yl)hydrazine
1.4.3.4 0.081
-
-
 Homo sapiens [2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.4 0.09
-
-
 Homo sapiens [2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
1.4.3.4 0.25
-
-
 Homo sapiens 2-(aminooxy)-1-phenylethanol
1.4.3.4 0.35
-
-
 Homo sapiens (2-methylprop-2-en-1-yl)hydrazine
1.4.3.4 0.45
-
-
 Homo sapiens 2-(aminooxy)-1-phenylethanol
1.4.3.4 8.2
-
-
 Homo sapiens 2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
1.4.3.21 0.0000017
-
-
 Rattus norvegicus 1-[2-(4-fluorophenyl)prop-2-en-1-yl]-2-methylhydrazine
1.4.3.21 0.000002
-
-
 Rattus norvegicus (2-phenylprop-2-en-1-yl)hydrazine
1.4.3.21 0.0000026
-
-
 Homo sapiens 2-(4-[2-[2-(acetylamino)-2,3-dihydro-1,3-thiazol-4-yl]ethyl]phenyl)-N-[amino(imino)methyl]acetamide
1.4.3.21 0.000003
-
-
 Rattus norvegicus [2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.21 0.000004
-
-
 Rattus norvegicus [2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
1.4.3.21 0.000004
-
-
 Homo sapiens 2-([[4-(1,1-dimethylpropyl)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide
1.4.3.21 0.0000045
-
-
 Homo sapiens N-[4-[2-(4-carbamimidamidophenyl)ethyl]-5-(4-sulfamoylbenzyl)-1,3-thiazol-2-yl]acetamide
1.4.3.21 0.000005
-
-
 Rattus norvegicus [(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
1.4.3.21 0.0000053
-
-
 Homo sapiens N-[4-(2-[4-[(2-amino-1H-imidazol-5-yl)methyl]phenyl]ethyl)-1,3-thiazol-2-yl]acetamide
1.4.3.21 0.000006
-
-
 Rattus norvegicus [2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.21 0.00001
-
-
 Rattus norvegicus 2-amino-N-[2-fluoro-5-(trifluoromethyl)benzyl]acetamide
1.4.3.21 0.000015
-
-
 Rattus norvegicus 2-amino-N-[2-fluoro-3-(trifluoromethyl)benzyl]acetamide
1.4.3.21 0.000033
-
-
 Rattus norvegicus 2-amino-N-[3-fluoro-5-(trifluoromethyl)benzyl]acetamide
1.4.3.21 0.000033
-
-
 Homo sapiens N-[2-(hydroxyamino)-2-oxoethyl]-2-(2-methyl-1H-indol-3-yl)acetamide
1.4.3.21 0.000035
-
-
 Bos taurus (2-phenylprop-2-en-1-yl)hydrazine
1.4.3.21 0.00005
-
-
 Bos taurus 2-(aminooxy)-1-phenylethanol
1.4.3.21 0.000054
-
-
 Homo sapiens N,3-dihydroxy-2-[(2-naphthylsulfonyl)amino]butanamide
1.4.3.21 0.000055
-
-
 Bos taurus (2-methylprop-2-en-1-yl)hydrazine
1.4.3.21 0.000078
-
-
 Homo sapiens 1-(isoquinolin-1-ylcarbonyl)pyrrolidine-2-carboxamide
1.4.3.21 0.00009
-
-
 Bos taurus 2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
1.4.3.21 0.0001
-
-
 Homo sapiens 4-bromo-N-[2-(hydroxyamino)-2-oxoethyl]benzamide
1.4.3.21 0.000125
-
-
 Homo sapiens 2-[(biphenyl-4-ylacetyl)amino]pentanedioic acid
1.4.3.21 0.000146
-
-
 Homo sapiens 4-amino-3-hydroxy-N-(3-phenylpropyl)benzamide
1.4.3.21 0.00015
-
-
 Homo sapiens N-[4-[2-(4-[[amino(imino)methyl]amino]phenyl)ethyl]-1,3-thiazol-2-yl]acetamide
1.4.3.21 0.00018
-
-
 Rattus norvegicus 2-amino-N-[4-fluoro-3-(trifluoromethyl)benzyl]acetamide
1.4.3.21 0.00023
-
-
 Rattus norvegicus 1-ethyl-2-[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
1.4.3.21 0.0005
-
-
 Rattus norvegicus 3-[2-(3-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrole
1.4.3.21 0.000575
-
-
 Homo sapiens 5-amino-2-hydroxy-N-(3-phenylpropyl)benzamide
1.4.3.21 0.00075
-
-
 Bos taurus 2-(2,5-dihydro-1H-pyrrol-3-yl)pyridine
1.4.3.21 0.00086
-
-
 Bos taurus 1-(2,5-dihydro-1H-pyrrol-3-yl)isoquinoline
1.4.3.21 0.00125
-
-
 Bos taurus buta-2,3-dien-1-amine
1.4.3.21 0.0015
-
-
 Bos taurus 3-(2,5-dihydro-1H-pyrrol-3-yl)pyridine
1.4.3.21 0.002
-
-
 Bos taurus (2E)-3-chloroprop-2-en-1-amine
1.4.3.21 0.0029
-
-
 Bos taurus but-3-yn-1-amine
1.4.3.21 0.01
-
-
 Bos taurus 3-bromoprop-2-yn-1-amine
1.4.3.21 0.011
-
-
 Bos taurus (2Z)-3-chloroprop-2-en-1-amine
1.4.3.21 0.013
-
-
 Bos taurus 4-aminobut-2-ynenitrile
1.4.3.21 0.02
-
-
 Bos taurus 4-(4-methoxyphenoxy)but-2-yn-1-amine
1.4.3.21 0.02
-
-
 Bos taurus 4-(4-nitrophenoxy)but-2-yn-1-amine
1.4.3.21 0.022
-
-
 Bos taurus 4-(4-methylphenoxy)but-2-yn-1-amine
1.4.3.21 0.025
-
-
 Bos taurus 4-(2-naphthyloxy)but-2-yn-1-amine
1.4.3.21 0.042
-
-
 Rattus norvegicus 3-(4-methoxyphenyl)-N-methyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
1.4.3.21 0.17
-
-
 Rattus norvegicus N-ethyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
1.4.3.21 0.2
-
-
 Bos taurus 4-phenoxybut-2-yn-1-amine
1.4.3.21 0.225
-
-
 Rattus norvegicus N-allyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide