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Literature summary extracted from

  • Bretillon, L.; Diczfalusy, U.; Bjoerkhem, I.; Maire, M.A.; Martine, L.; Joffre, C.; Acar, N.; Bron, A.; Creuzot-Garcher, C.
    Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina (2007), Curr. Eye Res., 32, 361-366.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Rattus norvegicus the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Bos taurus the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Bos taurus
-
 calf
-
1.14.14.25 Rattus norvegicus
-
 Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 additional information immunohistochemic analysis of enzyme distribution Rattus norvegicus
-
1.14.14.25 additional information immunohistochemic analysis of enzyme distribution Bos taurus
-
1.14.14.25 neuron of the neural retina, specific expression of CYP46A1 Rattus norvegicus
-
1.14.14.25 neuron of the neural retina, specific expression of CYP46A1 Bos taurus
-
1.14.14.25 retina specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body Rattus norvegicus
-
1.14.14.25 retina specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Rattus norvegicus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Bos taurus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview Rattus norvegicus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 the enzyme is important in cholesterol homeostasis in cerebral structures, CYP46A1 might be involved in retinal pathologies like age-related macular degeneration or glaucomas, overview Bos taurus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Rattus norvegicus
1.14.14.25 NADPH
-
 Bos taurus