Literature summary extracted from

Apud, J.A.; Weinberger, D.R.
Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors (2007), CNS Drugs, 21, 535-557.

Application

EC Number	Application	Comment	Organism
2.1.1.6	medicine	a functional COMT polymorphism (Val158Met) predicts performance in tasks of prefrontal executive function and the neurophysiological response measured with electroencephalography and functional magnetic resonance imaging in tasks assessing working memory. In fact, individuals with the Val/Val genotype, which encodes for the high-activity enzyme resulting in lower dopamine concentrations in the prefrontal cortex, perform less well and are less efficient physiologically than Met/Met individuals	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.6	tolcapone	possibility of genotype-targeted pharmacology for the treatment of cognitive dysfunction associated with schizophrenia. Even though tolcapone has proved useful in this regard, its hepatotoxicity proscribes its wide-spread use. The development of COMT inhibitors that can permeate the blood-brain barrier effectively and are devoid of serious adverse effects will allow expansion of the search for more specific, selective and effective therapies for the treatment of cognitive disorders	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.6	Homo sapiens	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.6	COMT	-	Homo sapiens

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Release 2023.1 (January 2023)