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Literature summary extracted from

  • Gardiner, S.J.; Gearry, R.B.; Begg, E.J.; Zhang, M.; Barclay, M.L.
    Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold (2008), Clin. Gastroenterol. Hepatol., 6; 654-60, quiz 604.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine patients with inflammatory bowel disease may have different thiopurine dose requirements in relation to thiopurine methyltransferase genotype or phenotype Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 blood
-
 Homo sapiens
-
2.1.1.67 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine monophosphate
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioinosine monophosphate
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine methyltransferase
-
 Homo sapiens
2.1.1.67 TPMT
-
 Homo sapiens