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Literature summary extracted from

  • Tahan, F.; Jazrawi, E.; Moodley, T.; Rovati, G.E.; Adcock, I.M.
    Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity (2008), Clin. Exp. Allergy, 38, 805-811.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.48 TNF-alpha a significant induction of NF-kB p65-associated HAT activity by TNF-alpha is demonstrated, which is attenuated by the presence of montelukast in a concentration-dependent manner Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 montelukast decreases HAT activity by attenuating the activating effect of TNF-alpha Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4
-
 Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 HAT
-
 Homo sapiens
2.3.1.48 histone acetyltransferase
-
 Homo sapiens