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Literature summary extracted from

  • Sharma, R.; Hoskins, J.M.; Rivory, L.P.; Zucknick, M.; London, R.; Liddle, C.; Clarke, S.J.
    Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients (2008), Clin. Cancer Res., 14, 817-825.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.20 A222V mutant with reduced enzymatic activity, predicts serum folate and plasma homocysteine levels and is useful for predicting toxicity from capecitabine in patients with advanced colorectal cancer Homo sapiens
1.5.1.20 E429A mutant with reduced enzymatic activity, predicts serum folate and plasma homocysteine levels and is useful for predicting toxicity from capecitabine in patients with advanced colorectal cancer Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.20 blood
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
Homo sapiens
1.5.1.20 MTHFR
-
Homo sapiens