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Literature summary extracted from

  • Chan, J.Y.; Takeda, M.; Briggs, L.E.; Graham, M.L.; Lu, J.T.; Horikoshi, N.; Weinberg, E.O.; Aoki, H.; Sato, N.; Chien, K.R.; Kasahara, H.
    Identification of cardiac-specific myosin light chain kinase (2008), Circ. Res., 102, 571-580.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.18 DNA and amino acid sequence determination and analysis, expression analysis in cardiac smooth muscle, overview, expression of HA-tagged MLCK Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.18 0.0043
-
 myosin light chain cardiac MLCK Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.18 cytoplasm subcellular localization study Mus musculus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain 2 Mus musculus MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview ADP + myosin light chain 2 phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Mus musculus Q6PDN3
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.18 phosphoprotein the cardiac-specific isozyme probably performs also autophosphorylation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 cardiomyocyte
-
 Mus musculus
-
2.7.11.18 heart cardiac-specific myosin light chain kinase Mus musculus
-
2.7.11.18 smooth muscle cardiac Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain 2
-
 Mus musculus ADP + myosin light chain 2 phosphate
-
 ?
2.7.11.18 ATP + myosin light chain 2 MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview Mus musculus ADP + myosin light chain 2 phosphate
-
 ?
2.7.11.18 additional information the cardiac-specific isozyme probably performs also autophosphorylation Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 cardiac-specific myosin light chain kinase
-
 Mus musculus
2.7.11.18 MLCK
-
 Mus musculus
2.7.11.18 myosin light chain kinase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Mus musculus