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Literature summary extracted from

  • Widder, J.D.; Chen, W.; Li, L.; Dikalov, S.; Thoeny, B.; Hatakeyama, K.; Harrison, D.G.
    Regulation of tetrahydrobiopterin biosynthesis by shear stress (2007), Circ. Res., 101, 830-838.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.153 additional information the enzyme activity is not affected by laminar shear stress in endothelial cells, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 additional information the enzyme activity is not affected by laminar shear stress in endothelial cells, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Homo sapiens
-
 tetrahydrobiopterin + NADP+
-
 r
1.1.1.153 additional information Homo sapiens the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis ?
-
 ?
1.1.1.153 sepiapterin + NADPH + H+ Homo sapiens
-
 7,8-dihydrobiopterin + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 epithelial cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.153 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
 Homo sapiens tetrahydrobiopterin + NADP+
-
 r
1.1.1.153 additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis Homo sapiens ?
-
 ?
1.1.1.153 sepiapterin + NADPH + H+
-
 Homo sapiens 7,8-dihydrobiopterin + NADP+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADP+
-
 Homo sapiens
1.1.1.153 NADPH
-
 Homo sapiens