Literature summary extracted from

Wang, D.; Gill, P.S.; Chabrashvili, T.; Onozato, M.L.; Raggio, J.; Mendonca, M.; Dennehy, K.; Li, M.; Modlinger, P.; Leiper, J.; Vallance, P.; Adler, O.; Leone, A.; Tojo, A.; Welch, W.J.; Wilcox, C.S.
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO (2007), Circ. Res., 101, 627-635.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.3.18	Rattus norvegicus	Q6MG60	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.5.3.18	blood vessel	DDAH-2 is strongly expressed in blood vessels	Rattus norvegicus	-
3.5.3.18	liver	expression of mRNA for DDAH-1 is 7fold higher in the liver compared to DDAH-2	Rattus norvegicus	-
3.5.3.18	renal cortex	expression of mRNA for DDAH-1 is 2fold higher in the renal cortex compared to DDAH-2	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.3.18	NG,NG-dimethyl-L-arginine + H2O	-	Rattus norvegicus	dimethylamine + L-citrulline	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.3.18	DDAH-2	isozyme	Rattus norvegicus
3.5.3.18	dimethylarginine dimethylaminohydrolase	-	Rattus norvegicus

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Release 2023.1 (January 2023)