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Literature summary extracted from

  • Nesterov, A.; Zhao, J.; Minter, D.; Hertel, C.; Ma, W.; Abeysinghe, P.; Hong, M.; Jia, Q.
    1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane, a novel tyrosinase inhibitor with strong depigmenting effects (2008), Chem. Pharm. Bull., 56, 1292-1296.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane tyrosinase inhibitor with strong depigmenting effects, found in the medicinal plant Dianella ensifolia. Synthetic and plant derived versions of the enzyme inhibit mushroom tyrosinase with similar potencies Agaricus bisporus
1.14.18.1 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane tyrosinase inhibitor with strong depigmenting effects, found in the medicinal plant Dianella ensifolia. 22times more potent than kojic acid Mus musculus
1.14.18.1 2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol plant-derived diarylpropane tyrosinase inhibitor Agaricus bisporus
1.14.18.1 4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol plant-derived diarylpropane tyrosinase inhibitor Agaricus bisporus
1.14.18.1 kojic acid commonly used tyrosinase inhibitor Agaricus bisporus
1.14.18.1 kojic acid
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-
1.14.18.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 B16-F1 cell mouse melanoma cell Mus musculus
-
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Mus musculus L-dopaquinone + H2O
-
 ?
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 dopa oxidase DOPA oxidase activity of murine tyrosinase Mus musculus
1.14.18.1 tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.0003
-
 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane inhibition is competitive and reversible, about 15times more potent than kojic acid Agaricus bisporus
1.14.18.1 0.0043
-
 kojic acid
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.00024
-
-
 Agaricus bisporus 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
1.14.18.1 0.001
-
-
 Agaricus bisporus 2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol
1.14.18.1 0.012
-
-
 Mus musculus 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
1.14.18.1 0.024
-
-
 Agaricus bisporus 4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol
1.14.18.1 0.273
-
-
 Mus musculus kojic acid