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Literature summary extracted from

  • Liu, S.; Venot, A.; Meng, L.; Tian, F.; Moremen, K.W.; Boons, G.; Prestegard, J.H.
    Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha -2,6-sialyltransferase ST6Gal I (2007), Chem. Biol., 14, 409-418.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.1 CMP-4-O-[2,2,6,6-tetramethylpiperidine-1-oxyl]
-
 Rattus norvegicus
2.4.3.1 CMP-4-O-[4-carboxy-2,2,6,6-tetramethylpiperidinine-1-oxyl]
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Rattus norvegicus P13721
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + N-acetyllactosamine
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 alpha-2,6-sialyltransferase
-
 Rattus norvegicus
2.4.3.1 ST6Gal I
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.3.1 0.79
-
 CMP-4-O-[4-carboxy-2,2,6,6-tetramethylpiperidinine-1-oxyl] pH 6.5, 37°C Rattus norvegicus
2.4.3.1 4.07
-
 CMP-4-O-[2,2,6,6-tetramethylpiperidine-1-oxyl] pH 6.5, 37°C Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.3.1 1.7
-
 pH 6.5, 37°C Rattus norvegicus CMP-4-O-[4-carboxy-2,2,6,6-tetramethylpiperidinine-1-oxyl]
2.4.3.1 8.7
-
 pH 6.5, 37°C Rattus norvegicus CMP-4-O-[2,2,6,6-tetramethylpiperidine-1-oxyl]