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Literature summary extracted from
- The N-acylethanolamine-hydrolyzing acid amidase (NAAA) (2007), Chem. Biodivers., 4, 1914-1925.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.4 | dithiothreitol | activates | Homo sapiens |  |
| 3.5.1.4 | dithiothreitol | activates | Rattus norvegicus | |
| 3.5.1.4 | dithiothreitol | activates | Mus musculus | |
| 3.5.1.4 | additional information | no activation by dithiothreitol | Mus musculus | |
| 3.5.1.4 | additional information | no activation by dithiothreitol | Rattus norvegicus | |
| 3.5.1.4 | additional information | no activation by dithiothreitol | Homo sapiens | |
| 3.5.1.4 | additional information | no activation by dithiothreitol | Sus scrofa |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.4 | DNA containing thymine glycol | - |
Homo sapiens | |
| 3.5.1.4 | DNA containing thymine glycol | - |
Mus musculus | |
| 3.5.1.4 | DNA containing thymine glycol | - |
Rattus norvegicus | |
| 3.5.1.4 | DNA containing thymine glycol | - |
Sus scrofa | |
| 3.5.1.4 | N-(cyclohexylcarbonyl)pentadecylamine | - |
Homo sapiens | |
| 3.5.1.4 | N-(cyclohexylcarbonyl)pentadecylamine | - |
Mus musculus | |
| 3.5.1.4 | N-(cyclohexylcarbonyl)pentadecylamine | - |
Rattus norvegicus | |
| 3.5.1.4 | PCMB | - |
Homo sapiens | |
| 3.5.1.4 | PCMB | - |
Mus musculus | |
| 3.5.1.4 | PCMB | - |
Rattus norvegicus | |
| 3.5.1.4 | PMSF | - |
Homo sapiens | |
| 3.5.1.4 | PMSF | - |
Mus musculus | |
| 3.5.1.4 | PMSF | - |
Rattus norvegicus | |
| 3.5.1.4 | PMSF | - |
Sus scrofa | |
| 3.5.1.4 | URB597 | - |
Homo sapiens | |
| 3.5.1.4 | URB597 | - |
Mus musculus | |
| 3.5.1.4 | URB597 | - |
Rattus norvegicus | |
| 3.5.1.4 | URB597 | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.5.1.4 | lysosome | - |
Homo sapiens | 5764 | - |
| 3.5.1.4 | lysosome | - |
Rattus norvegicus | 5764 | - |
| 3.5.1.4 | lysosome | - |
Mus musculus | 5764 | - |
| 3.5.1.4 | membrane | - |
Mus musculus | 16020 | - |
| 3.5.1.4 | membrane | - |
Rattus norvegicus | 16020 | - |
| 3.5.1.4 | membrane | - |
Homo sapiens | 16020 | - |
| 3.5.1.4 | membrane | - |
Sus scrofa | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.4 | Homo sapiens | O00519 | - |
- |
| 3.5.1.4 | Homo sapiens | Q02083 | - |
- |
| 3.5.1.4 | Mus musculus | O08914 | - |
- |
| 3.5.1.4 | Mus musculus | Q9D7V9 | - |
- |
| 3.5.1.4 | Rattus norvegicus | P97612 | - |
- |
| 3.5.1.4 | Rattus norvegicus | Q5KTC7 | - |
- |
| 3.5.1.4 | Sus scrofa | Q9TUI8 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.4 | brain | - |
Mus musculus | - |
| 3.5.1.4 | brain | - |
Rattus norvegicus | - |
| 3.5.1.4 | brain | - |
Homo sapiens | - |
| 3.5.1.4 | brain | - |
Sus scrofa | - |
| 3.5.1.4 | liver | - |
Mus musculus | - |
| 3.5.1.4 | liver | - |
Rattus norvegicus | - |
| 3.5.1.4 | liver | - |
Homo sapiens | - |
| 3.5.1.4 | liver | - |
Sus scrofa | - |
| 3.5.1.4 | lung | - |
Homo sapiens | - |
| 3.5.1.4 | lung | - |
Rattus norvegicus | - |
| 3.5.1.4 | lung | - |
Mus musculus | - |
| 3.5.1.4 | small intestine | - |
Homo sapiens | - |
| 3.5.1.4 | small intestine | - |
Rattus norvegicus | - |
| 3.5.1.4 | small intestine | - |
Mus musculus | - |
| 3.5.1.4 | small intestine | - |
Sus scrofa | - |
| 3.5.1.4 | spleen | - |
Homo sapiens | - |
| 3.5.1.4 | spleen | - |
Rattus norvegicus | - |
| 3.5.1.4 | spleen | - |
Mus musculus | - |
| 3.5.1.4 | testis | - |
Mus musculus | - |
| 3.5.1.4 | testis | - |
Rattus norvegicus | - |
| 3.5.1.4 | testis | - |
Homo sapiens | - |
| 3.5.1.4 | testis | - |
Sus scrofa | - |
| 3.5.1.4 | thymus | - |
Homo sapiens | - |
| 3.5.1.4 | thymus | - |
Rattus norvegicus | - |
| 3.5.1.4 | thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.4 | 2-arachidonoylglycerol + H2O | - |
Homo sapiens | arachidonic acid + glycerol | - |
? | |
| 3.5.1.4 | 2-arachidonoylglycerol + H2O | - |
Sus scrofa | arachidonic acid + glycerol | - |
? | |
| 3.5.1.4 | 2-arachidonoylglycerol + H2O | - |
Mus musculus | ? | - |
? | |
| 3.5.1.4 | 2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Mus musculus | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Rattus norvegicus | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Sus scrofa | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Rattus norvegicus | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | anandamide + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Mus musculus | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.4 | additional information | hardly hydrolyzes 2-arachidonoylglycerol | Homo sapiens | ? | - |
? | |
| 3.5.1.4 | additional information | hardly hydrolyzes 2-arachidonoylglycerol | Rattus norvegicus | ? | - |
? | |
| 3.5.1.4 | additional information | hardly hydrolyzes 2-arachidonoylglycerol | Mus musculus | ? | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Mus musculus | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Rattus norvegicus | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Sus scrofa | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Rattus norvegicus | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-oleoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Mus musculus | oleic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Mus musculus | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Rattus norvegicus | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Sus scrofa | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Rattus norvegicus | palmitic acid + ethanolamine | - |
? | |
| 3.5.1.4 | N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Mus musculus | palmitic acid + ethanolamine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.4 | FAAH-1 | - |
Mus musculus |
| 3.5.1.4 | FAAH-1 | - |
Rattus norvegicus |
| 3.5.1.4 | FAAH-1 | - |
Homo sapiens |
| 3.5.1.4 | FAAH-1 | - |
Sus scrofa |
| 3.5.1.4 | fatty acid amide hydrolase 1 | - |
Mus musculus |
| 3.5.1.4 | fatty acid amide hydrolase 1 | - |
Rattus norvegicus |
| 3.5.1.4 | fatty acid amide hydrolase 1 | - |
Homo sapiens |
| 3.5.1.4 | fatty acid amide hydrolase 1 | - |
Sus scrofa |
| 3.5.1.4 | N-acylethanolaminehydrolyzing acid amidase | - |
Homo sapiens |
| 3.5.1.4 | N-acylethanolaminehydrolyzing acid amidase | - |
Rattus norvegicus |
| 3.5.1.4 | N-acylethanolaminehydrolyzing acid amidase | - |
Mus musculus |
| 3.5.1.4 | NAAA | - |
Homo sapiens |
| 3.5.1.4 | NAAA | - |
Rattus norvegicus |
| 3.5.1.4 | NAAA | - |
Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.4 | 4.5 | 5 | - |
Homo sapiens |
| 3.5.1.4 | 4.5 | 5 | - |
Rattus norvegicus |
| 3.5.1.4 | 4.5 | 5 | - |
Mus musculus |
| 3.5.1.4 | 8.5 | 10 | - |
Mus musculus |
| 3.5.1.4 | 8.5 | 10 | - |
Rattus norvegicus |
| 3.5.1.4 | 8.5 | 10 | - |
Homo sapiens |
| 3.5.1.4 | 8.5 | 10 | - |
Sus scrofa |
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