Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Carbone, V.; Hara, A.; El-Kabbani, O.
    Structural and functional features of dimeric dihydrodiol dehydrogenase (2008), Cell. Mol. Life Sci., 65, 1464-1474.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.20
-
 Macaca fascicularis

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.20 F279A the mutation affects inhibition and substrate affinity Macaca fascicularis
1.3.1.20 K97M mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH Macaca fascicularis
1.3.1.20 K97R mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH Macaca fascicularis
1.3.1.20 W125A the mutation affects inhibition and substrate affinity Macaca fascicularis
1.3.1.20 W254A the mutation affects inhibition and substrate affinity Macaca fascicularis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.20 2,6-dihydroxyanthraquinone competitive inhibitor Macaca fascicularis
1.3.1.20 2,6-dihydroxyanthraquinone competitive inhibitor Sus scrofa
1.3.1.20 4-hydroxyacetophenone competitive inhibitor Macaca fascicularis
1.3.1.20 4-hydroxyacetophenone competitive inhibitor Sus scrofa
1.3.1.20 isoascorbic acid competitive inhibitor Macaca fascicularis
1.3.1.20 isoascorbic acid competitive inhibitor Sus scrofa
1.3.1.20 L-ascorbic acid competitive inhibitor Macaca fascicularis
1.3.1.20 L-ascorbic acid competitive inhibitor Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.1.20 Mg2+ activates Sus scrofa
1.3.1.20 Mg2+ activates Macaca fascicularis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.20 Bos taurus Q148L6
-
-
1.3.1.20 Macaca fascicularis
-
-
-
1.3.1.20 Mus musculus Q9DBB8
-
-
1.3.1.20 Pongo abelii Q5R5J5
-
-
1.3.1.20 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.20 kidney
-
 Macaca fascicularis
-
1.3.1.20 lens
-
 Mus musculus
-
1.3.1.20 additional information not found in liver and kidney Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.20 camphorquinone + NAD(P)H
-
 Sus scrofa (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
 ?
1.3.1.20 camphorquinone + NAD(P)H
-
 Macaca fascicularis (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
 ?
1.3.1.20 camphorquinone + NAD(P)H
-
 Mus musculus (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
 ?
1.3.1.20 camphorquinone + NAD(P)H
-
 Pongo abelii (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
 ?
1.3.1.20 camphorquinone + NAD(P)H
-
 Bos taurus (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
 ?
1.3.1.20 D-xylose + NADP+
-
 Sus scrofa D-xylono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 D-xylose + NADP+
-
 Macaca fascicularis D-xylono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 D-xylose + NADP+
-
 Mus musculus D-xylono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 D-xylose + NADP+
-
 Pongo abelii D-xylono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 D-xylose + NADP+
-
 Bos taurus D-xylono-1,5-lactone + NADPH + H+
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Sus scrofa catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Macaca fascicularis catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Mus musculus catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Pongo abelii catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Bos taurus catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?

Subunits

EC Number Subunits Comment Organism
1.3.1.20 dimer x-ray crystallography Sus scrofa
1.3.1.20 dimer x-ray crystallography Macaca fascicularis

Synonyms

EC Number Synonyms Comment Organism
1.3.1.20 DHDH
-
 Sus scrofa
1.3.1.20 DHDH
-
 Macaca fascicularis
1.3.1.20 DHDH
-
 Mus musculus
1.3.1.20 DHDH
-
 Pongo abelii
1.3.1.20 DHDH
-
 Bos taurus
1.3.1.20 dihydrodiol dehydrogenase
-
 Sus scrofa
1.3.1.20 dihydrodiol dehydrogenase
-
 Macaca fascicularis
1.3.1.20 dihydrodiol dehydrogenase
-
 Mus musculus
1.3.1.20 dihydrodiol dehydrogenase
-
 Pongo abelii
1.3.1.20 dihydrodiol dehydrogenase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.20 NAD+
-
 Sus scrofa
1.3.1.20 NAD+
-
 Macaca fascicularis
1.3.1.20 NAD+
-
 Mus musculus
1.3.1.20 NAD+
-
 Pongo abelii
1.3.1.20 NAD+
-
 Bos taurus
1.3.1.20 NADP+ dependent on Sus scrofa
1.3.1.20 NADP+ dependent on Macaca fascicularis
1.3.1.20 NADP+ dependent on Mus musculus
1.3.1.20 NADP+ dependent on Pongo abelii
1.3.1.20 NADP+ dependent on Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.20 0.043
-
-
 Sus scrofa isoascorbic acid
1.3.1.20 0.45
-
-
 Sus scrofa L-ascorbic acid