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Literature summary extracted from

  • Alonso, M.; Burgos, H.I.; Pannunzio, V.; Hughes, A.M.; Mattoon, J.R.; Stella, C.A.
    Brefeldin A decreases the activity of the general amino acid permease (GAP1) and the more specific systems for L-leucine uptake in Saccharomyces cerevisiae (2006), Cell. Mol. Biol. Lett., 11, 256-263.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.4.2.1 additional information brefeldin A decreases uptake of L-Leu, substance probably acts via direct or indirect modification of the transporting protein, which affects the kinetic parameters Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.1 ATP + H2O + amino acid/out Saccharomyces cerevisiae amino acid uptake, catalyzes the transport of all the D- and L-isomers of the amino acids normally found in proteins ADP + phosphate + amino acid/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.1 Saccharomyces cerevisiae
-
 wild type strain MMY2 and gap1-knockout mutant
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.1 ATP + H2O + amino acid/out amino acid uptake, catalyzes the transport of all the D- and L-isomers of the amino acids normally found in proteins Saccharomyces cerevisiae ADP + phosphate + amino acid/in
-
 ?
7.4.2.1 ATP + H2O + L-citrulline/out
-
 Saccharomyces cerevisiae ADP + phosphate + L-citrulline/in
-
 ?
7.4.2.1 ATP + H2O + L-Leu/out
-
 Saccharomyces cerevisiae ADP + phosphate + L-Leu/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.1 GAP1
-
 Saccharomyces cerevisiae
7.4.2.1 gap1 gene product
-
 Saccharomyces cerevisiae
7.4.2.1 general amino acid permease catalyzes the transport of all the D- and L-isomers of the amino acids normally found in proteins Saccharomyces cerevisiae
7.4.2.1 More displays also EC 3.6.3.21 /nonpolar-amino-acid-transporting ATPase activity Saccharomyces cerevisiae