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Literature summary extracted from

  • Vande Walle, L.; Lamkanfi, M.; Vandenabeele, P.
    The mitochondrial serine protease HtrA2/Omi: an overview (2008), Cell Death Differ., 15, 453-460.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 additional information HtrA2/Omi protein levels are upregulated several fold when the unfolded protein response is triggered by heat shock. Transient exposure to elevated temperatures augments the protease activity of human HtrA2/Omi Homo sapiens
3.4.21.108 siRNA siRNA-mediated knockdown of HtrA2/Omi combined with the pan-caspase inhibitor zVAD-fmk almost completely protects HeLa cells from undergoing staurosporine-induced cell death, whereas caspase inhibition alone is significantly less effective Homo sapiens
3.4.21.108 tunicamycin
-
 Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.108 medicine link between HtrA2/Omi and Parkinson’s disease or Alzheimer’s disease Homo sapiens
3.4.21.108 medicine role for HtrA2/Omi in apoptosis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 A141S affects the enzymatic activity of the protease, associated with the development of Parkinson’s disease Homo sapiens
3.4.21.108 G399S affects the enzymatic activity of the protease, associated with the development of Parkinson’s disease Homo sapiens
3.4.21.108 additional information mutations in the genes encoding HtrA proteins correlate with Parkinson’s disease. Lower HtrA2/Omi phosphorylation levels in brains of patients with Parkinson’s disease carrying mutations in PINK1 Homo sapiens
3.4.21.108 additional information mutations in the genes encoding HtrA proteins correlate with perinatal lethality in mice Mus musculus
3.4.21.108 S276C HtrA2/Omi appears to be correctly processed in cells derived from Mnd2 mice (motor neuron degeneration 2), which are homozygous for a naturally occurring Ser276Cys mutation in the HtrA2/Omi protease domain that greatly reduces its catalytic activity. Mnd2 mice display Parkinsonian phenotype, fail to gain weight, and organs such as the heart, thymus and spleen are dramatically smaller when compared to wild-type littermates. Reduced body weight and progressive loss of neurons in the striatum of the basal ganglia are also evident in mice with a targeted deletion of the HtrA2/Omi gene. HtrA2/Omi-/- mice display a lack of coordination, decreased mobility and tremor Mus musculus
3.4.21.108 S306A enzymatically inactive, remains uncleaved Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 ucf-101
-
 Homo sapiens
3.4.21.108 ucf-101
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion intermembrane space, HtrA2/Omi is required for mitochondrial homeostasis Mus musculus 5739
-
3.4.21.108 mitochondrion intermembrane space, HtrA2/Omi is required for mitochondrial homeostasis Homo sapiens 5739
-
3.4.21.108 nucleus
-
 Homo sapiens 5634
-
3.4.21.108 periplasm
-
 Escherichia coli
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Bacillus sp. (in: Bacteria)
-
-
-
3.4.21.108 Bos taurus
-
-
-
3.4.21.108 Canis lupus familiaris
-
-
-
3.4.21.108 Clostridium sp.
-
-
-
3.4.21.108 Drosophila melanogaster
-
-
-
3.4.21.108 Escherichia coli
-
-
-
3.4.21.108 Homo sapiens
-
-
-
3.4.21.108 Macaca mulatta
-
-
-
3.4.21.108 Mesorhizobium loti
-
-
-
3.4.21.108 Mus musculus
-
-
-
3.4.21.108 no activity in Caenorhabditis elegans
-
-
-
3.4.21.108 no activity in Mycoplasma genitalium
-
-
-
3.4.21.108 no activity in Mycoplasma pneumoniae
-
-
-
3.4.21.108 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 brain
-
 Homo sapiens
-
3.4.21.108 HeLa cell
-
 Homo sapiens
-
3.4.21.108 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 HS1-associated protein X-1 + H2O HtrA2/Omi-mediated degradation of HS1-associated protein X-1 correlates with extensive cell death in response to etoposide, cisplatin and H2O2 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA/DegP
-
 Escherichia coli
3.4.21.108 HtrA2/Omi
-
 Drosophila melanogaster
3.4.21.108 HtrA2/Omi
-
 Mus musculus
3.4.21.108 HtrA2/Omi
-
 Homo sapiens
3.4.21.108 HtrA2/Omi
-
 Rattus norvegicus
3.4.21.108 HtrA2/Omi
-
 Bos taurus
3.4.21.108 HtrA2/Omi
-
 Canis lupus familiaris
3.4.21.108 HtrA2/Omi
-
 Bacillus sp. (in: Bacteria)
3.4.21.108 HtrA2/Omi
-
 Macaca mulatta
3.4.21.108 HtrA2/Omi
-
 Clostridium sp.
3.4.21.108 HtrA2/Omi
-
 Mesorhizobium loti
3.4.21.108 serine protease HtrA2/Omi
-
 Drosophila melanogaster
3.4.21.108 serine protease HtrA2/Omi
-
 Mus musculus
3.4.21.108 serine protease HtrA2/Omi
-
 Homo sapiens
3.4.21.108 serine protease HtrA2/Omi
-
 Rattus norvegicus
3.4.21.108 serine protease HtrA2/Omi
-
 Bos taurus
3.4.21.108 serine protease HtrA2/Omi
-
 Canis lupus familiaris
3.4.21.108 serine protease HtrA2/Omi
-
 Bacillus sp. (in: Bacteria)
3.4.21.108 serine protease HtrA2/Omi
-
 Macaca mulatta
3.4.21.108 serine protease HtrA2/Omi
-
 Clostridium sp.
3.4.21.108 serine protease HtrA2/Omi
-
 Mesorhizobium loti

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.4.21.108 additional information
-
 functions as a chaperonin at normal temperatures, but relies on its proteolytic activity to prevent the accumulation of misfolded proteins in the periplasmic space at higher temperatures Escherichia coli