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Literature summary extracted from

  • Amegadzie, B.Y.; Hanning, C.R.; McLaughlin, M.M.; Burman, M.; Cieslinski, L.B.; Livi, G.P.; Torphy, T.J.
    Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells (1995), Cell Biol. Int., 19, 477-484.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53 expression in Spodoptera frugiperda Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 R-rolipram
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.003
-
 adenosine 3',5'-cyclic phosphate
-
 Homo sapiens
3.1.4.53 0.0038
-
 adenosine 3',5'-cyclic phosphate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O
-
 Homo sapiens adenosine 5'-phosphate
-
 ?
3.1.4.53 additional information no activity with cGMP Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 hPDE4A
-
 Homo sapiens
3.1.4.53 hPDE4B
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.53 0.00025
-
 R-rolipram
-
 Homo sapiens
3.1.4.53 0.00038
-
 R-rolipram
-
 Homo sapiens