Literature summary extracted from

Rennison, J.H.; McElfresh, T.A.; Okere, I.C.; Patel, H.V.; Foster, A.B.; Patel, K.K.; Stoll, M.S.; Minkler, P.E.; Fujioka, H.; Hoit, B.D.; Young, M.E.; Hoppel, C.L.; Chandler, M.P.
Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure (2008), Cardiovasc. Res., 79, 331-340.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.3.8.7	additional information	administration of a high fat diet in heart failure rats increases MCAD activity	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.3.1.8	mitochondrion	-	Rattus norvegicus	5739	-
1.3.8.7	mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.3.1.8	(2E)-hexadec-2-enoyl-CoA + NADPH	Rattus norvegicus	-	palmitoyl-CoA + NADP+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.8	Rattus norvegicus	-	-	-
1.3.8.7	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.1.8	heart	-	Rattus norvegicus	-
1.3.8.7	heart	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.1.8	(2E)-hexadec-2-enoyl-CoA + NADPH	-	Rattus norvegicus	palmitoyl-CoA + NADP+	-	?
1.3.1.8	2-trans-octenoyl-CoA + NADPH	-	Rattus norvegicus	octanoyl-CoA + NADP+	-	?
1.3.1.8	crotonyl-CoA + NADPH	-	Rattus norvegicus	butyryl-CoA + NADP+	-	?
1.3.8.7	acyl-CoA + acceptor	-	Rattus norvegicus	2,3-dehydroacyl-CoA + reduced acceptor	-	?
1.3.8.7	octanoyl-CoA + acceptor	-	Rattus norvegicus	2-octenoyl-CoA + reduced acceptor	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.3.1.8	MCAD	-	Rattus norvegicus
1.3.1.8	medium-chain acyl-CoA dehydrogenase	-	Rattus norvegicus
1.3.8.7	MCAD	-	Rattus norvegicus
1.3.8.7	medium chain acyl-CoA dehydrogenase	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.3.1.8	NADPH	-	Rattus norvegicus

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Release 2023.1 (January 2023)