EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.5.4.1 | additional information | low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview | Escherichia coli |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.4.1 | medicine | the enzyme is useful in gene therapy for treatment of cancer, bladder tumor model, overview | Escherichia coli |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.4.1 | expression of the recombinant fusion gene from adenoviral vector under control of the human telomerase reverse transcriptase promoter in murine syngeneic MBT-2 bladder tumor cells, overview | Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.4.1 | additional information | construction of a fusion gene in an adenoviral vector comprising human telomerase reverse transcriptase promoter, and cytosine deaminase from Escherichia coli | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.1 | cytosine + H2O | Escherichia coli | - |
uracil + NH3 | - |
? | |
3.5.4.1 | additional information | Escherichia coli | low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.4.1 | Escherichia coli | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.1 | 5-fluorocytosine + H2O | - |
Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
3.5.4.1 | cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
3.5.4.1 | additional information | low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview | Escherichia coli | ? | - |
? |