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Literature summary extracted from

  • Zhou, X.; Liu, Y.; You, J.; Zhang, H.; Zhang, X.; Ye, L.
    Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2 (2008), Cancer Lett., 270, 312-327.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 ML-7 ie. 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazapine hydrochloride, a specific inhibitor of MLCK, ML-7 is able to depress the cell proliferation and migration in vivo using two parallel breast cancer cell lines. ML-7 not only blocks MLCK but also downregulates activated ERK1/2 with downstream effectors of beta-catenin-survivin-cyclin D1-c-Myc, overview Homo sapiens
2.7.11.18 additional information the inhibitor of ERK1/2, PD98059, downregulates the levels of MLCK and phosphorylated myosin light chain Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Homo sapiens MLCK plays a crucial role in the cell migration and tumor metastasis ADP + myosin light chain phosphate
-
?
2.7.11.18 additional information Homo sapiens myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens Q15746
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 breast cancer cell
-
Homo sapiens
-
2.7.11.18 MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
Homo sapiens ADP + myosin light chain phosphate
-
?
2.7.11.18 ATP + myosin light chain MLCK plays a crucial role in the cell migration and tumor metastasis Homo sapiens ADP + myosin light chain phosphate
-
?
2.7.11.18 additional information myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
Homo sapiens
2.7.11.18 myosin light-chain kinase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
Homo sapiens