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Literature summary extracted from

  • Tammali, R.; Ramana, K.V.; Srivastava, S.K.
    Aldose reductase regulates TNF-alpha -induced PGE2 production in human colon cancer cells (2007), Cancer Lett., 252, 299-306.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.21 medicine inhibition/antisense abolition of aldose reductase inhibits the tumor necrosis factor alpha-induced synthesis of prostaglandin E2 and the activity of cyclooxygenase. Inhibition of aldose reductase prevents tumor necrosis factor alpha-induced activation of protein kinase C and NF-kappaB which results in the abrogation of Cox-2 mRNA and protein expression Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.21 additional information transient transfection of Caco-2 cells with aldose reductase antisense but not scrambled antisense oligonucleotides abolishes aldose reductase protein by more than 95%. Antisense abolition significantly prevents the tumor necrosis factor alpha-induced prostaglandin E2 production in Caco-2 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 sorbinil inhibition significantly prevents the tumor necrosis factor alpha-induced prostaglandin E2 production in Caco-2 cells Homo sapiens
1.1.1.21 Tolrestat inhibition significantly prevents the tumor necrosis factor alpha-induced prostaglandin E2 production in Caco-2 cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 Caco-2 cell
-
 Homo sapiens
-