Literature summary extracted from

Li, B.; Guo, Y.S.; Sun, M.M.; Dong, H.; Wu, S.Y.; Wu, D.X.; Li, C.Y.
The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury (2008), Brain Res., 1226, 199-208.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.6.3.1	lipopolysaccharide	exposure tolipopolysaccharide leads to the demise of motor neurons in a dose- and time-dependent manner, whereas interneurons are impaired relatively mildly. NADPH oxidase is activated upon lipopolysaccharide challenge, and inhibitor apocynin prevents inflammation-mediated toxicity to motor neurons	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.6.3.1	apocynin	prevents inflammation-mediated toxicity to motor neurons induced by lipopolysaccharide	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.3.1	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.3.1	brain	-	Rattus norvegicus	-
1.6.3.1	spinal cord	lumbal spinal cord slice	Rattus norvegicus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)