Literature summary extracted from

Tobin, J.E.; Cui, J.; Wilk, J.B.; Latourelle, J.C.; Laramie, J.M.; McKee, A.C.; Guttman, M.; Karamohamed, S.; DeStefano, A.L.; Myers, R.H.
Sepiapterin reductase expression is increased in Parkinsons disease brain tissue (2007), Brain Res., 1139, 42-47.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.153	chromosomal location 2p14-2p12, RT-PCR expression analysis	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.153	additional information	a single nucleotide polymorphism around the SPR gene is involved in development of Parkonson's disease	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.153	6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH	Homo sapiens	-	tetrahydrobiopterin + NADP+	the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine	r
1.1.1.153	additional information	Homo sapiens	the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue	?	-	?
1.1.1.153	sepiapterin + NADPH + H+	Homo sapiens	-	7,8-dihydrobiopterin + NADP+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.153	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.153	brain	sepiapterin reductase expression is increased in Parkinsons disease brain tissue	Homo sapiens	-
1.1.1.153	cerebellum	post-mortem semi-quantitative expression analysis in brain of control individuals and Parkinson disease patients, SPR expression is increased in Parkinson patients, but not in the other genes involved in the tetrahydrobiopterin biosynthesis, overview	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.153	6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH	-	Homo sapiens	tetrahydrobiopterin + NADP+	-	r
1.1.1.153	6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH	-	Homo sapiens	tetrahydrobiopterin + NADP+	the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine	r
1.1.1.153	additional information	the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue	Homo sapiens	?	-	?
1.1.1.153	sepiapterin + NADPH + H+	-	Homo sapiens	7,8-dihydrobiopterin + NADP+	-	r

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Release 2023.1 (January 2023)