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Literature summary extracted from

  • Donate, F.; Juarez, J.C.; Burnett, M.E.; Manuia, M.M.; Guan, X.; Shaw, D.E.; Smith, E.L.; Timucin, C.; Braunstein, M.J.; Batuman, O.A.; Mazar, A.P.
    Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224) (2008), Br. J. Cancer, 98, 776-783.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.15.1.1 drug development the enzyme is a target for development of antiangiogenic and antitumour drugs Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 tetrathiomolybdate i.e. ATN-224, choline salt, inhibition leads to antiangiogenic and antitumour effects Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2.- + H+ Mus musculus enzyme inhibition by tetrathiomolybdate leads to antiangiogenic and antitumour effects in mice O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 erythrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2.- + H+
-
 Mus musculus O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ enzyme inhibition by tetrathiomolybdate leads to antiangiogenic and antitumour effects in mice Mus musculus O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 CuZn superoxide dismutase 1
-
 Mus musculus
1.15.1.1 SOD1
-
 Mus musculus
1.15.1.1 superoxide dismutase 1
-
 Mus musculus