EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.18.2 | DNA and amino acid sequence determination of wild-type and mutant alleles, genotyping and expression analysis, overview | Felis catus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.18.2 | G1266A | naturally occuring silent mtation | Felis catus |
1.14.18.2 | G139A | naturally occuring missense mutation | Felis catus |
1.14.18.2 | G1600A | naturally occuring silent mtation | Felis catus |
1.14.18.2 | additional information | mutations in type B cats likely disrupt the gene function of CMAH, leading to a predominance of NeuAc in blood types, genotyping, overview | Felis catus |
1.14.18.2 | T265A | naturally occuring missense mutation | Felis catus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.2 | Fe2+ | in cofactor ferrocytochrome b5 | Felis catus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.2 | CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+ | Felis catus | the enzyme determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types, two major serotypes. Blood type A is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined: N-glycolylneuraminic acid, NeuGc, is associated with type A and N-acetylneuraminic acid, NeuAc, with type B, overview | CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.2 | Felis catus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.2 | CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+ | - |
Felis catus | CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O | - |
? | |
1.14.18.2 | CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+ | the enzyme determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types, two major serotypes. Blood type A is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined: N-glycolylneuraminic acid, NeuGc, is associated with type A and N-acetylneuraminic acid, NeuAc, with type B, overview | Felis catus | CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.18.2 | CMAH | - |
Felis catus |
1.14.18.2 | cytidine monophospho-N-acetylneuraminic acid hydroxylase | - |
Felis catus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.2 | ferrocytochrome b5 | - |
Felis catus |