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Literature summary extracted from

  • Bighignoli, B.; Niini, T.; Grahn, R.A.; Pedersen, N.C.; Millon, L.V.; Polli, M.; Longeri, M.; Lyons, L.A.
    Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group (2007), BMC Genet., 8, 27.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.2 DNA and amino acid sequence determination of wild-type and mutant alleles, genotyping and expression analysis, overview Felis catus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.18.2 G1266A naturally occuring silent mtation Felis catus
1.14.18.2 G139A naturally occuring missense mutation Felis catus
1.14.18.2 G1600A naturally occuring silent mtation Felis catus
1.14.18.2 additional information mutations in type B cats likely disrupt the gene function of CMAH, leading to a predominance of NeuAc in blood types, genotyping, overview Felis catus
1.14.18.2 T265A naturally occuring missense mutation Felis catus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.2 Fe2+ in cofactor ferrocytochrome b5 Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+ Felis catus the enzyme determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types, two major serotypes. Blood type A is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined: N-glycolylneuraminic acid, NeuGc, is associated with type A and N-acetylneuraminic acid, NeuAc, with type B, overview CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O
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Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Felis catus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+
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Felis catus CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O
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1.14.18.2 CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 + H+ the enzyme determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types, two major serotypes. Blood type A is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined: N-glycolylneuraminic acid, NeuGc, is associated with type A and N-acetylneuraminic acid, NeuAc, with type B, overview Felis catus CMP-N-glycoloylneuraminate + ferricytochrome b5 + H2O
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?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.2 CMAH
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Felis catus
1.14.18.2 cytidine monophospho-N-acetylneuraminic acid hydroxylase
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Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 ferrocytochrome b5
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Felis catus