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Literature summary extracted from

  • Sparey, T.; Abeywickrema, P.; Almond, S.; Brandon, N.; Byrne, N.; Campbell, A.; Hutson, P.H.; Jacobson, M.; Jones, B.; Munshi, S.; Pascarella, D.; Pike, A.; Prasad, G.S.; Sachs, N.; Sakatis, M.; Sardana, V.; Venkatraman, S.; Young, M.B.
    The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 3386-3391.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 1H-indole-2-carboxylic acid
-
 Homo sapiens
1.4.3.3 1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1.4.3.3 2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 2-(2,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 2-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 2-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-(hydroxymethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-cyano-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 3-pyridin-3-yl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 4,5-dichlorofuran-2-carboxylic acid
-
 Homo sapiens
1.4.3.3 4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-3-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-pyrrolo[2,3-d][1,3]oxazole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 6-chloro-1,2-benzisoxazol-3-ol
-
 Homo sapiens
1.4.3.3 6H-thieno[2,3-b]pyrrole-5-carboxylic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens P14920
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Homo sapiens
1.4.3.3 DAO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.3 0.000141
-
-
 Homo sapiens 4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.000238
-
-
 Homo sapiens 4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-3-carboxylic acid
1.4.3.3 0.000245
-
-
 Homo sapiens 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.000269
-
-
 Homo sapiens 6H-thieno[2,3-b]pyrrole-5-carboxylic acid
1.4.3.3 0.000343
-
-
 Homo sapiens 4,5-dichlorofuran-2-carboxylic acid
1.4.3.3 0.000507
-
-
 Homo sapiens 6-chloro-1,2-benzisoxazol-3-ol
1.4.3.3 0.000516
-
-
 Homo sapiens 4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid
1.4.3.3 0.000745
-
-
 Homo sapiens 1H-indole-2-carboxylic acid
1.4.3.3 0.001153
-
-
 Homo sapiens 3-cyano-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.001426
-
-
 Homo sapiens 3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.004204
-
-
 Homo sapiens 4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 3-pyridin-3-yl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 3-(hydroxymethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 3-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 3-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 4H-pyrrolo[2,3-d][1,3]oxazole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 1H-pyrrole-2-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2-(2,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.005
-
 IC50 above 0.005 mM Homo sapiens 1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylic acid