EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.26 | pharmacology | ACAT-1 and ACAT-2 selective inhibitors may prove to have clinical benefit to reduce atherosclerosis via directly reducing the size of the lipid-rich core in the atherosclerotic plaques or the absorption of cholesterol in intestine, respectively | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.26 | a stable cell line expressing hACAT-1 from AC-29 cells is established | Homo sapiens |
2.3.1.26 | a stable cell line expressing hACAT-2 from AC-29 cells is established | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (9Z,12E)-octadeca-9,12-dienoate | - |
Homo sapiens | |
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate | - |
Homo sapiens | |
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate | - |
Homo sapiens | |
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate | - |
Homo sapiens | |
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate | - |
Homo sapiens | |
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate | - |
Homo sapiens | |
2.3.1.26 | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate | - |
Homo sapiens | |
2.3.1.26 | acetylshikonin | - |
Homo sapiens | |
2.3.1.26 | beta-hydroxyisovalerylshikonin | - |
Homo sapiens | |
2.3.1.26 | isobutyrylshikonin | - |
Homo sapiens | |
2.3.1.26 | shikonin | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.26 | acyl-CoA + cholesterol | Homo sapiens | - |
CoA + cholesterol ester | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.26 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.26 | acyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesterol ester | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.26 | ACAT-1 | - |
Homo sapiens |
2.3.1.26 | ACAT-2 | - |
Homo sapiens |
2.3.1.26 | acyl-CoA:cholesterol acyltransferase | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.26 | 0.0138 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate | |
2.3.1.26 | 0.0224 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate | |
2.3.1.26 | 0.0251 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate | |
2.3.1.26 | 0.0287 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate | |
2.3.1.26 | 0.0307 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate | |
2.3.1.26 | 0.0496 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate | |
2.3.1.26 | 0.0537 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate | |
2.3.1.26 | 0.0562 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate | |
2.3.1.26 | 0.0575 | - |
- |
Homo sapiens | isobutyrylshikonin | |
2.3.1.26 | 0.0704 | - |
- |
Homo sapiens | shikonin | |
2.3.1.26 | 0.0714 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate | |
2.3.1.26 | 0.0776 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate | |
2.3.1.26 | 0.0845 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate | |
2.3.1.26 | 0.0948 | - |
- |
Homo sapiens | (1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate | |
2.3.1.26 | 0.1122 | - |
- |
Homo sapiens | acetylshikonin | |
2.3.1.26 | 0.1289 | - |
- |
Homo sapiens | acetylshikonin | |
2.3.1.26 | 0.1382 | - |
- |
Homo sapiens | shikonin | |
2.3.1.26 | 0.1698 | - |
- |
Homo sapiens | beta-hydroxyisovalerylshikonin | |
2.3.1.26 | 0.1869 | - |
- |
Homo sapiens | beta-hydroxyisovalerylshikonin |