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Literature summary extracted from

  • McCarthy, O.K.; Schipani, A.; Buendia, A.M.; Ruiz-Perez, L.M.; Kaiser, M.; Brun, R.; Pacanowska, D.G.; Gilbert, I.H.
    Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase (2006), Bioorg. Med. Chem. Lett., 16, 3809-3812.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 dUMP product inhibition Trypanosoma cruzi
3.6.1.23 additional information computational docking of small molecules structures to the enzyme for inhibitor development, overview Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-D-alanyl-L-tyrosine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-aspartic acid
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-glutamic acid
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-glutamine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-lysine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-threonine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanylglycine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-lysine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-threonine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-tyrosine
-
 Trypanosoma cruzi
3.6.1.23 N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycylglycine
-
 Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Trypanosoma cruzi
-
 dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Trypanosoma cruzi dUMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 dUTPase
-
 Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.23 additional information
-
 additional information Ki of developed inhibitors higher than 1 mM Trypanosoma cruzi
3.6.1.23 0.0184
-
 dUMP
-
 Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.1.23 additional information
-
 IC50 values of the inhibitor cytotoxicity assay on rat LC6 cells, overview Trypanosoma cruzi additional information
3.6.1.23 0.074
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-D-alanyl-L-tyrosine
3.6.1.23 0.076
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-tyrosine
3.6.1.23 0.081
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-glutamine
3.6.1.23 0.081
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-glutamic acid
3.6.1.23 0.081
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-lysine
3.6.1.23 0.084
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-aspartic acid
3.6.1.23 0.084
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-lysine
3.6.1.23 0.087
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-threonine
3.6.1.23 0.091
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-threonine
3.6.1.23 0.1
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanylglycine
3.6.1.23 0.132
-
-
 Trypanosoma cruzi N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycylglycine