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Literature summary extracted from

  • Sadeghian, H.; Seyedi, S.M.; Saberi, M.R.; Arghiani, Z.; Riazi, M.
    Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors (2008), Bioorg. Med. Chem., 16, 890-901.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 4-allyl-2-methoxyphenyl 1-adamantanecarboxylate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 1-adamantanecarboxylate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 2-chlorobenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 2-chlorobenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 2-fluorobenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 2-fluorobenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 2-methylbenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 2-methylbenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 2-pyridinecarboxylate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 2-pyridinecarboxylate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 3-chlorobenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 3-chlorobenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 3-fluorobenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 3-fluorobenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 3-methoxybenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 3-methoxybenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 3-methylbenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 3-methylbenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 4-chlorobenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 4-chlorobenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 4-fluorobenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 4-fluorobenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 4-methoxybenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 4-methoxybenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl 4-methylbenzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl 4-methylbenzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl benzoate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl benzoate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl isonicotinate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl isonicotinate
-
 Homo sapiens
1.13.11.33 4-allyl-2-methoxyphenyl nicotinate
-
 Glycine max
1.13.11.33 4-allyl-2-methoxyphenyl nicotinate
-
 Homo sapiens
1.13.11.33 additional information quantitative structure activity relationship analysis using crystal structure, PDB ID 1IK3, EC 1.13.11.12, of the enzyme in complex with 13(S)-hydroperoxy-9(Z)-2,11(E)-octadecadienoic acid, docking studies, inhibitor binding structures, overview Glycine max
1.13.11.33 additional information docking studies, inhibitor binding structures, overview Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Glycine max
-
-
-
1.13.11.33 Homo sapiens
-
 isozymes 15-HLOa and 15-HLOb
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 linoleic acid + O2 reaction of EC 1.13.11.12 Glycine max (9Z,11E)-(13S)-13-hydroperoxy-octadeca-9,11-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-hLO
-
 Homo sapiens
1.13.11.33 15-lipoxygenase
-
 Homo sapiens
1.13.11.33 15-lipoxygenase
-
 Glycine max
1.13.11.33 arachidonic acid 15-lipoxygenase
-
 Glycine max
1.13.11.33 More cf. EC 1.13.11.12 Glycine max
1.13.11.33 SLO
-
 Glycine max
1.13.11.33 soybean 15-lipoxygenase
-
 Glycine max
1.13.11.33 soybean lipoxygenase-3
-
 Glycine max

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.33 additional information
-
 additional information
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.000017
-
-
 Glycine max 4-allyl-2-methoxyphenyl 1-adamantanecarboxylate
1.13.11.33 0.0017
-
-
 Glycine max 4-allyl-2-methoxyphenyl nicotinate
1.13.11.33 0.0021
-
-
 Glycine max 4-allyl-2-methoxyphenyl 3-fluorobenzoate
1.13.11.33 0.0022
-
-
 Glycine max 4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate
1.13.11.33 0.0023
-
-
 Glycine max 4-allyl-2-methoxyphenyl isonicotinate
1.13.11.33 0.0044
-
-
 Glycine max 4-allyl-2-methoxyphenyl benzoate
1.13.11.33 0.0052
-
-
 Glycine max 4-allyl-2-methoxyphenyl 3-chlorobenzoate
1.13.11.33 0.0067
-
-
 Glycine max 4-allyl-2-methoxyphenyl 2-fluorobenzoate
1.13.11.33 0.0072
-
-
 Glycine max 4-allyl-2-methoxyphenyl 4-fluorobenzoate
1.13.11.33 0.0114
-
-
 Glycine max 4-allyl-2-methoxyphenyl 3-methylbenzoate
1.13.11.33 0.0146
-
-
 Glycine max 4-allyl-2-methoxyphenyl 4-methylbenzoate
1.13.11.33 0.019
-
-
 Glycine max 4-allyl-2-methoxyphenyl 4-methoxybenzoate
1.13.11.33 0.023
-
-
 Glycine max 4-allyl-2-methoxyphenyl 3-methoxybenzoate
1.13.11.33 0.0333
-
-
 Glycine max 4-allyl-2-methoxyphenyl 2-pyridinecarboxylate
1.13.11.33 0.0772
-
-
 Glycine max 4-allyl-2-methoxyphenyl 2-methylbenzoate
1.13.11.33 0.1343
-
-
 Glycine max 4-allyl-2-methoxyphenyl 4-chlorobenzoate
1.13.11.33 0.168
-
-
 Glycine max 4-allyl-2-methoxyphenyl 2-chlorobenzoate