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Literature summary extracted from

  • Russell, W.R.; Scobbie, L.; Duthie, G.G.; Chesson, A.
    Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids (2008), Bioorg. Med. Chem., 16, 4589-4593.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 2,3-Dihydroxybenzoic acid 47.7% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 2,4-dihydroxybenzoic acid 49.9% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 2,5-dihydroxybenzoic acid 21.2% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 2-hydroxybenzoic acid 46.0% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 3,4,5-Trihydroxybenzoic acid 60.5% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 3,4-dihydroxybenzoic acid 51.6% inhibition at 0.015 mM, active site binding structure; 73.3% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 3,5-Dihydroxybenzoic acid 58.1% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 3-Hydroxybenzoic acid 47.6% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 4-hydroxy-3-methoxybenzoic acid 45.4% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 4-hydroxybenzoic acid 47.0% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 benzoic acid 48.4% inhibition at 0.015 mM, active site binding structure Glycine max
1.13.11.33 caffeic acid 36.2% inhibition at 0.015 mM Glycine max
1.13.11.33 additional information no inhibition by 2,6-dihydroxybenzoic acid Glycine max

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Glycine max
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Glycine max (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase
-
 Glycine max