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Literature summary extracted from
- Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors (2008), Bioorg. Med. Chem., 16, 3245-3254.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.209 | chrysin | - |
Mus musculus |  |
| 1.1.1.209 | fidarestat | - |
Mus musculus | |
| 1.1.1.209 | minalrestat | inhibition pattern for AKR1C21, overview | Mus musculus | |
| 1.1.1.209 | additional information | enzyme-inhibitor complexe modelling, Tyr118 and Phe311 are important residues for inhibitor recognition and orientation in the active site of AKR1C21, overview | Mus musculus | |
| 1.1.1.209 | myricetin | - |
Mus musculus | |
| 1.1.1.209 | quercetin | inhibition pattern for AKR1C21, overview | Mus musculus | |
| 1.1.1.209 | quercitrin | - |
Mus musculus | |
| 1.1.1.209 | sorbinil | - |
Mus musculus | |
| 1.1.1.209 | Tolrestat | inhibition pattern for AKR1C21, overview | Mus musculus | |
| 1.1.1.209 | zopolrestat | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.209 | additional information | Mus musculus | the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.209 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.209 | additional information | the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.209 | 3(17)alpha-hydroxysteroid dehydrogenase | - |
Mus musculus |
| 1.1.1.209 | AKR1C21 | - |
Mus musculus |
| 1.1.1.209 | More | AKR1C21 is a member of the aldo-keto reductase superfamily | Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.209 | 25 | - |
assay at | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.209 | 7.4 | - |
assay at | Mus musculus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.209 | 0.000009 | - |
pH 7.4, 25°C | Mus musculus | fidarestat | |
| 1.1.1.209 | 0.00003 | - |
pH 7.4, 25°C | Mus musculus | zopolrestat | |
| 1.1.1.209 | 0.00004 | - |
pH 7.4, 25°C | Mus musculus | Tolrestat | |
| 1.1.1.209 | 0.00007 | - |
pH 7.4, 25°C | Mus musculus | minalrestat | |
| 1.1.1.209 | 0.00015 | - |
pH 7.4, 25°C | Mus musculus | quercitrin | |
| 1.1.1.209 | 0.00091 | - |
pH 7.4, 25°C | Mus musculus | sorbinil | |
| 1.1.1.209 | 0.0022 | - |
pH 7.4, 25°C | Mus musculus | quercetin | |
| 1.1.1.209 | 0.0085 | - |
pH 7.4, 25°C | Mus musculus | chrysin | |
| 1.1.1.209 | 0.029 | - |
pH 7.4, 25°C | Mus musculus | myricetin | |
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Release 2023.1 (January 2023)
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