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Literature summary extracted from

  • Silva, P.J.; Ramos, M.J.
    A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase (2008), Bioorg. Med. Chem., 16, 2726-2733.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Homo sapiens
-
-
-
1.3.3.3 synthetic construct
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O reaction starts by O2 addition to the pyrrole substrate yielding a hydroperoxide, which then abstracts a proton from the reactive propionate substituent, and the reaction may then proceed through H2O elimination, followed by decarboxylation synthetic construct
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ O2 is added to the (preferentially deprotonated) pyrrole substrate (yielding a hydroperoxide, which then abstracts a proton from the reactive propionate substituent), the reaction may then proceed through HO2- elimination, followed by decarboxylation Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2H+
-
 Homo sapiens protoporphyrinogen IX + 2 CO2 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 coproporphyrinogen III oxidase
-
 Homo sapiens
1.3.3.3 O2-dependent coproporphyrinogen III oxidase
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 Homo sapiens