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Literature summary extracted from

  • Pak, V.V.; Koo, M.; Kim, M.J.; Yun, L.; Kwon, D.Y.
    Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone (2008), Bioorg. Med. Chem., 16, 1309-1318.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 F(4-fluoro)VAE HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 FVAE HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 GFPDGG designed on the basis of the rigid peptide backbone, increases the inhibitory potency more than 300 times compared to the first isolated LPYP from soybean, overview Rattus norvegicus
1.1.1.34 GFPEGG HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 GFPTGG HMG-CoA competitive inhibitor; NADPH and HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 GLPDGG NADPH and HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 GLPEGG NADPH and HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 GLPTGG NADPH and HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 IAVE HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 IAVP NADPH competitive inhibitor Rattus norvegicus
1.1.1.34 IAVPGEVA isolated from soybean by pepsin Rattus norvegicus
1.1.1.34 IVAE HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 LPYP from soybean Rattus norvegicus
1.1.1.34 YAVE HMG-CoA competitive inhibitor Rattus norvegicus
1.1.1.34 YVAE HMG-CoA competitive inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+ Rattus norvegicus
-
 mevalonate + NADP+ + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+
-
 Rattus norvegicus mevalonate + NADP+ + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG-CoA reductase
-
 Rattus norvegicus
1.1.1.34 HMGR
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.34 0.0015
-
-
 Rattus norvegicus GFPDGG
1.1.1.34 0.0017
-
-
 Rattus norvegicus GFPEGG
1.1.1.34 0.0038
-
-
 Rattus norvegicus F(4-fluoro)VAE
1.1.1.34 0.0169
-
-
 Rattus norvegicus GFPTGG
1.1.1.34 0.0194
-
-
 Rattus norvegicus GLPTGG
1.1.1.34 0.0223
-
-
 Rattus norvegicus GLPDGG
1.1.1.34 0.0272
-
-
 Rattus norvegicus GLPEGG
1.1.1.34 0.0418
-
-
 Rattus norvegicus YVAE
1.1.1.34 0.0438
-
-
 Rattus norvegicus FVAE
1.1.1.34 0.0441
-
-
 Rattus norvegicus IVAE
1.1.1.34 0.0526
-
-
 Rattus norvegicus YAVE
1.1.1.34 0.0752
-
-
 Rattus norvegicus IAVE
1.1.1.34 0.097
-
-
 Rattus norvegicus IAVP
1.1.1.34 0.152
-
-
 Rattus norvegicus IAVPGEVA
1.1.1.34 0.484
-
-
 Rattus norvegicus LPYP