Literature summary extracted from

El-Hamamsy, M.H.; Smith, A.W.; Thompson, A.S.; Threadgill, M.D.
Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis (2007), Bioorg. Med. Chem., 15, 4552-4576.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.5.1.3	expression in Escherichia coli	Homo sapiens
1.5.1.3	expression in Escherichia coli	Mycobacterium tuberculosis

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.5.1.3	4,5-dideoxy-5-(2,6-diamino-5-phenylpyrimidin-4-yl)-D-erythro-pentitol	selective inhibition, little effect on human or yeast enzyme	Mycobacterium tuberculosis
1.5.1.3	5-phenyl-6-((3R,4S)-3,4,5-trihydroxypentyl)pyrimidine-2,4-diamine	selective inhibition of Mycobacterium tuberculosis enzyme, little effect on human or yeast enzyme	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.3	Homo sapiens	-	-	-
1.5.1.3	Mycobacterium tuberculosis	-	-	-

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Release 2023.1 (January 2023)