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Literature summary extracted from

  • Hsieh, J.F.; Wu, S.H.; Yang, Y.L.; Choong, K.F.; Chen, S.T.
    The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors (2007), Bioorg. Med. Chem., 15, 3450-3456.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 1,2,4-triazolo[1,5-a]pyrimidine poor inhibitor Homo sapiens
1.17.3.2 2,6-diaminopurine poor inhibitor Homo sapiens
1.17.3.2 2-amino-6-chloropurine poor inhibitor Homo sapiens
1.17.3.2 2-Aminopurine poor inhibitor Homo sapiens
1.17.3.2 2-chloro-6(methylamino)purine competitive Homo sapiens
1.17.3.2 4-Aminopyrazolo[3,4-d]pyrimidine competitive Homo sapiens
1.17.3.2 5,6-Dimethylbenzimidazole poor inhibitor Homo sapiens
1.17.3.2 5-methylbenzimidazole poor inhibitor Homo sapiens
1.17.3.2 5-nitrobenzimidazole
-
 Homo sapiens
1.17.3.2 6-aminopurine
-
 Homo sapiens
1.17.3.2 6-O-methylguanine poor inhibitor Homo sapiens
1.17.3.2 6-thioguanine
-
 Homo sapiens
1.17.3.2 allopurinol
-
 Homo sapiens
1.17.3.2 additional information screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors isolated from Triticum aestivum leaves water extracts, structure determination by mass spectrometry and NMR spectrometry analysis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Homo sapiens production of superoxide radicals urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Homo sapiens urate + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.5
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.3.2 additional information
-
 additional information inhibition kinetics Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 0.0078
-
 pH 7.5, 25°C Homo sapiens allopurinol
1.17.3.2 0.0102
-
 pH 7.5, 25°C Homo sapiens 2-chloro-6(methylamino)purine
1.17.3.2 0.0109
-
 pH 7.5, 25°C Homo sapiens 6-aminopurine
1.17.3.2 0.0303
-
 pH 7.5, 25°C Homo sapiens 4-Aminopyrazolo[3,4-d]pyrimidine
1.17.3.2 0.0868
-
 pH 7.5, 25°C Homo sapiens 5-nitrobenzimidazole
1.17.3.2 0.0924
-
 pH 7.5, 25°C Homo sapiens 6-thioguanine