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Literature summary extracted from
- Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum (2007), Bioorg. Med. Chem., 15, 2708-2714.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | (7S, 8R, 8'R)-(-)-lariciresinol-4'-O-beta-D-glucopyranoside | tyrosinase inhibitors from Marrubium velutinum, lignan glucosides | Agaricus bisporus |  |
| 1.14.18.1 | (7S, 8R, 8'R)-(-)-lariciresinol-4,4'-O-bis-beta-D-glucopyranoside | tyrosinase inhibitors from Marrubium velutinum, lignan glucosides | Agaricus bisporus | |
| 1.14.18.1 | (7S, 8R, 8'R)-(-)-lariciresinol-4-O-beta-D-glucopyranoside | tyrosinase inhibitors from Marrubium velutinum, lignan glucosides | Agaricus bisporus | |
| 1.14.18.1 | 5,6,7,4'-tetramethylscutellarein | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols. Methoxylated flavones, like the methylethers of scutellarein, showed 10times lower inhibitory activity than kojic acid | Agaricus bisporus | |
| 1.14.18.1 | 5,6,7,8,4'-pentahydroxyflavone | tyrosinase inhibitors from Marrubium cylleneum, flavones/flavonols | Agaricus bisporus | |
| 1.14.18.1 | 5,7,4'-trimethylscutellarein | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols. Methoxylated flavones, like the methylethers of scutellarein, showed 10times lower inhibitory activity than kojic acid | Agaricus bisporus | |
| 1.14.18.1 | 6'-glucosyl-martynoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of 6'-glucosyl-martynoside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | 6-hydroxy-kaempferol-3-O-rutinoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | acteoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of acteoside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | alyssonoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| 1.14.18.1 | apigenin | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols | Agaricus bisporus | |
| 1.14.18.1 | apigenin-7-O-(3'',6''-di-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | apigenin-7-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | chlorogenic acid | tyrosinase inhibitors from Marrubium velutinum, phenolic acids | Agaricus bisporus | |
| 1.14.18.1 | chrysoeriol | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols | Agaricus bisporus | |
| 1.14.18.1 | chrysoeriol-7-O-(3'',6''-di-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | cistanoside F | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Comparing the activity of tetrasaccharides with cistanoside F | Agaricus bisporus | |
| 1.14.18.1 | echinacoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of echinacoside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | ferulic acid | tyrosinase inhibitors from Marrubium cylleneum, phenolic acids | Agaricus bisporus | |
| 1.14.18.1 | forsythoside B | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of for sythoside B in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | isoferulate | tyrosinase inhibitors from Marrubium cylleneum, phenolic acids | Agaricus bisporus | |
| 1.14.18.1 | isorhamnetin-3-O-(6''-OAc)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | isorhamnetin-3-O-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | isorhamnetin-3-O-rutinoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | isorhamnetin-7-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | kaempferol-3-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | kaempferol-3-O-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | kojic acid | postive control | Agaricus bisporus | |
| 1.14.18.1 | ladanein | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols. Methoxylated flavones, like the methylethers of scutellarein, showed 10times lower inhibitory activity than kojic acid | Agaricus bisporus | |
| 1.14.18.1 | lamiophlomiside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| 1.14.18.1 | lavandulifolioside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of lavandulifolioside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | leucosceptoside A | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of leucosceptoside A in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | luteolin-7-O-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | martynoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| 1.14.18.1 | additional information | flavonoids and phenylethanoid glycosides show moderate inhibitory activity against tyrosinase (almost 2-3times weaker than kojic acid). In general at lower concentrations activity descends as flavonols > flavones > acylated monoglycosides > monoglycosides > diglycosides | Agaricus bisporus | |
| 1.14.18.1 | nikotiflorin | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | p-coumaric acid | tyrosinase inhibitors from Marrubium cylleneum, phenolic acids | Agaricus bisporus | |
| 1.14.18.1 | phaselic acid | tyrosinase inhibitors from Marrubium velutinum, phenolic acids | Agaricus bisporus | |
| 1.14.18.1 | quercetin | tyrosinase inhibitors from Marrubium cylleneum, flavones/flavonols | Agaricus bisporus | |
| 1.14.18.1 | quercetin-3-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | rutin | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| 1.14.18.1 | stachydrine | tyrosinase inhibitors from Marrubium cylleneum, lignan glucosides | Agaricus bisporus | |
| 1.14.18.1 | stachysoside D | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| 1.14.18.1 | tiliroside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| 1.14.18.1 | velutinoside I | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| 1.14.18.1 | velutinoside II | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of velutinoside II in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 1.14.18.1 | velutinoside III | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| 1.14.18.1 | velutinoside IV | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | copper | copper containing enzyme. Bathochromic shift of selected phenylethanoid glycosides (0.01 mM) in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | polyphenol oxidase | - |
Agaricus bisporus |
| 1.14.18.1 | PPO | - |
Agaricus bisporus |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
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Release 2023.1 (January 2023)
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