Literature summary extracted from

Yang, E.S.; Lee, J.H.; Park, J.W.
Ethanol induces peroxynitrite-mediated toxicity through inactivation of NADP(+)-dependent isocitrate dehydrogenase and superoxide dismutase (2008), Biochimie, 90, 1316-1324.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.42	peroxynitrite	ethanol toxicity is mediated by peroxynitrite and the peroxynitrite-mediated damage to NADP+-dependent isocitrate dehydrogenase and superoxide dismutase may be resulting in the perturbation of the cellular antioxidant defense systems and subsequently lead to a pro-oxidant condition	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.42	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.42	Hep-G2 cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.42	ICDH	-	Homo sapiens
1.1.1.42	NADP+-dependent isocitrate dehydrogenase	-	Homo sapiens

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Release 2023.1 (January 2023)