BRENDA - Enzyme Database

Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase

Mizushina, Y.; Dairaku, I.; Yanaka, N.; Takeuchi, T.; Ishimaru, C.; Sugawara, F.; Yoshida, H.; Kato, N.; Biochimie 89, 581-590 (2007) View publication on PubMed

Data extracted from this reference:

Crystallization (Commentary)
EC Number
Crystallization (Commentary)
Organism
1.1.1.205
modeling of enzyme in complex with eicosadienoic acid. Eicosadienoic acid binds to residue C331 in the active site
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.205
eicosadienoic acid
competitive to inosine 5'-phosphate
Mus musculus
1.1.1.205
linoleic acid
-
Mus musculus
1.1.1.205
additional information
not inhibitory: linoelaidic acid, methyl linoleate, cis-9-octadecen-1-ol
Mus musculus
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.1.1.205
Mus musculus
-
IMPDH type II
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.1.1.205
inosine 5'-phosphate + NAD+ + H2O
-
685417
Mus musculus
xanthosine 5'-phosphate + NADH
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.1.1.205
0.0031
-
eicosadienoic acid
pH 8.0, 37°C
Mus musculus
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.1.1.205
0.0161
-
pH 8.0, 37°C
Mus musculus
eicosadienoic acid
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
1.1.1.205
modeling of enzyme in complex with eicosadienoic acid. Eicosadienoic acid binds to residue C331 in the active site
Mus musculus
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.1.1.205
0.0161
-
pH 8.0, 37°C
Mus musculus
eicosadienoic acid
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.205
eicosadienoic acid
competitive to inosine 5'-phosphate
Mus musculus
1.1.1.205
linoleic acid
-
Mus musculus
1.1.1.205
additional information
not inhibitory: linoelaidic acid, methyl linoleate, cis-9-octadecen-1-ol
Mus musculus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.1.1.205
0.0031
-
eicosadienoic acid
pH 8.0, 37°C
Mus musculus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.1.1.205
inosine 5'-phosphate + NAD+ + H2O
-
685417
Mus musculus
xanthosine 5'-phosphate + NADH
-
-
-
?