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Literature summary extracted from

  • Mizushina, Y.; Dairaku, I.; Yanaka, N.; Takeuchi, T.; Ishimaru, C.; Sugawara, F.; Yoshida, H.; Kato, N.
    Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase (2007), Biochimie, 89, 581-590.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.205 modeling of enzyme in complex with eicosadienoic acid. Eicosadienoic acid binds to residue C331 in the active site Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 eicosadienoic acid competitive to inosine 5'-phosphate Mus musculus
1.1.1.205 linoleic acid
-
 Mus musculus
1.1.1.205 additional information not inhibitory: linoelaidic acid, methyl linoleate, cis-9-octadecen-1-ol Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Mus musculus
-
 IMPDH type II
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Mus musculus xanthosine 5'-phosphate + NADH
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.0031
-
 eicosadienoic acid pH 8.0, 37°C Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.205 0.0161
-
 pH 8.0, 37°C Mus musculus eicosadienoic acid