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Literature summary extracted from

  • Layden, B.T.; Saengsawang, W.; Donati, R.J.; Yang, S.; Mulhearn, D.C.; Johnson, M.E.; Rasenick, M.M.
    Structural model of a complex between the heterotrimeric G protein, Gsalpha, and tubulin (2008), Biochim. Biophys. Acta, 1783, 964-973.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.1 tubulin direct transfer of GTP Bos taurus
3.6.5.6 Gsalpha Gsalpha facilitates GTP hydrolysis on tubulin, which leads to microtubule depolymerization by increased GTPase activation on tubulin Ovis aries

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.5.1
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.6 GTP + H2O Ovis aries
-
 GDP + phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.1 Bos taurus P04896
-
-
3.6.5.6 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.5.6 ovine brain tubulin is prepared from freshly-killed animals using phosphocellulose chromatography Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.6 brain
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.6 GTP + H2O
-
 Ovis aries GDP + phosphate
-
 ir

Subunits

EC Number Subunits Comment Organism
3.6.5.1 More domain alpha2-4 and domain alpha3-beta5 are important for interaction with tubulin Bos taurus
3.6.5.6 heterodimer consists of an alpha and beta monomer Ovis aries

Synonyms

EC Number Synonyms Comment Organism
3.6.5.1 heterotrimeric G protein Gsalpha
-
 Bos taurus
3.6.5.6 tubulin GTPase
-
 Ovis aries