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Literature summary extracted from

  • Lewin, T.M.; de Jong, H.; Schwerbrock, N.J.; Hammond, L.E.; Watkins, S.M.; Combs, T.P.; Coleman, R.A.
    Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition (2008), Biochim. Biophys. Acta, 1781, 352-358.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.15 N-ethylmaleimide only N-ethylmaleimide sensitive isoform Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 mitochondrial outer membrane heart Mus musculus 5741
-
2.3.1.15 mitochondrion heart Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate Mus musculus acylation of sn-glycerol 3-phosphate with longchain acyl-CoA CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.15 heart
-
 Mus musculus
-
2.3.1.15 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.15 0.00013
-
 in hearts from wild-type mice, N-ethylmaleimide resistant GPAT activity, 27% of the total activity Mus musculus
2.3.1.15 0.00025
-
 in hearts from wild-type mice, mitochondrial fraction, N-ethylmaleimide resistant GPAT activity, 43% of the total activity Mus musculus
2.3.1.15 0.00047
-
 in hearts from wild-type mice, total activity Mus musculus
2.3.1.15 0.00057
-
 in hearts from wild-type mice, mitochondrial fraction, total activity Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate acylation of sn-glycerol 3-phosphate with longchain acyl-CoA Mus musculus CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.15 glycerol-3-phosphate acyltransferase-1
-
 Mus musculus
2.3.1.15 GPAT1
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.15 20
-
 activity assay at room temperature Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.15 7.5
-
 activity assay Mus musculus