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Literature summary extracted from

  • Kawao, N.; Okada, K.; Kawata, S.; Okamoto, C.; Tsuritani, M.; Ueshima, S.; Matsuo, O.
    Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes (2007), Biochim. Biophys. Acta, 1773, 718-727.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.7 Aprotinin augments binding of hepatocytes from mice to immobilized plasmin Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.7 medicine the plasminogen/plasmin system decreases Bim(EL) expression and activation of caspase-3 via the ERK1/2 signaling pathway during liver regeneration, resulting in an enhancement of cell survival. Plasmin protects against starvation-induced apoptosis in primary hepatocytes of mice Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.7 Aprotinin inhibits plasmin-induced phosphorylation of ERK1/2 Homo sapiens
3.4.21.7 diisopropyl fluorophosphate does not block binding of hepatocytes from mice to immobilized plasmin, but blocks active site of plasmin and its ability to phosphorylate ERK1/2 Homo sapiens
3.4.21.7 epsilon-aminocaproic acid inhibits plasmin-induced phosphorylation of ERK1/2; lysine binding sites inhibitor, partially blocks binding of hepatocytes from mice to immobilized plasmin at 10 mM, but not at 0.01 mM Homo sapiens
3.4.21.7 MG-132 prevents facilitation of degradation of Bim(EL) by plasmin in hepatocytes from mice pretreated with cycloheximide Homo sapiens
3.4.21.7 PD98059 MEK inhibitor, completely abolishes plasmin-induced phosphorylation of ERK1/2 at 0.05 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.7 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.7 additional information plasmin triggeres phosphorylation of ERK1/2 in a concentration-dependent manner, but not of Akt Homo sapiens ?
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