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Literature summary extracted from

  • Aoyama, C.; Ishidate, K.; Sugimoto, H.; Vance, D.E.
    Induction of choline kinase alpha by carbon tetrachloride (CCl4) occurs via increased binding of c-jun to an AP-1 element (2007), Biochim. Biophys. Acta, 1771, 1148-1155.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.32 carbon tetrachloride CCl4, major increase in the transcript for choline kinase alpha expression in livers from mice 3 h and 6 h after administration of carbon tetrachloride. CK-beta is unaffected by the carbon tetrachloride treatment. Choline kinase activity is induced in murine livers by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK-alpha and Ck-alpha protein. Mus musculus
2.7.1.32 carbon tetrachloride CK activity is induced by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK alpha and CK alpha protein. The transcriptional activity of CK alpha was markedly increased 3 h and 6 h after treatment with carbon tetrachloride. Carbon tetrachloride promotes the expression of the transcription factor activator protein 1 (AP-1) that increases CK expression and activity. Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.32 a series of luciferase vectors that contained the CKalpha promoter and ranged from +57 to -3840 bp is constructed. The vectors are cotransfected into hepa-1 cells with the renilla luciferase expression vector as a control Mus musculus
2.7.1.32 To identify the region of the CK apha promoter that is important to regulate its transcription, a series of luciferase vectors that contained the CK alpha promoter and ranged from +57 to -3840 bp are constructed. The vectors are cotransfected into Hepa-1 cells with the renilla luciferase expression vector as a control Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.32 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.32 choline + ATP Mus musculus first enzyme in the CDP-choline (Kennedy) pathway for the biosynthesis of phosphatidylcholine phosphocholine + ADP choline kinase supply phosphocholine for the biosynthesis of phosphatidylcholine that is essential for growth and cell division ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Mus musculus
-
-
-
2.7.1.32 Mus musculus O54804
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.32 Hepa-1 cell
-
 Mus musculus
-
2.7.1.32 hepatoma cell line Hepa-1 Mus musculus
-
2.7.1.32 liver from male mice C57B16 (12 weeks old) Mus musculus
-
2.7.1.32 liver Male C57Bl6 mice (12 weeks old) are injected intraperitoneally with carbon tetrachloride dissolved in olive oil at the dosage of 3 ml/kg. Mice are killed at indicated times and the livers quickly removed. Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 choline + ATP first enzyme in the CDP-choline (Kennedy) pathway for the biosynthesis of phosphatidylcholine Mus musculus phosphocholine + ADP choline kinase supply phosphocholine for the biosynthesis of phosphatidylcholine that is essential for growth and cell division ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 choline kinase
-
 Mus musculus
2.7.1.32 choline kinase alpha
-
 Mus musculus
2.7.1.32 CK
-
 Mus musculus
2.7.1.32 CK-alpha1
-
 Mus musculus
2.7.1.32 CK-alpha2
-
 Mus musculus
2.7.1.32 CK-beta
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.32 ATP
-
 Mus musculus